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1、31stAnnualInternationalConferenceoftheIEEEEMBSMinneapolis,Minnesota,USA,September2-6,2009RespirationTriggeredMagneticDrugTargetingintheLungs111DahmaniCh.,GötzS.,WeyhTh.222RennerR.,RoseneckerM.,RudolphC.1TechnischeUniversitätMünchen,HeinzNixdorf-LehrstuhlfürMedizinischeElektronik,Munich,Germany2Ludwi
2、g-Maximilians-Universität,DepartmentofPediatrics,Munich,GermanyAbstract—Lungcancerkillsperyear1.3millionpeopleDuetothestrongdependenceontherespirationflow,theworldwide.Itisthemostfatalcancertypeasfarasmenareexactreproductionofagivendrugdistributioninthelungsconcernedandtheseconddeadliestforwomen.rem
3、ainsaprincipalissue[5].OneoftherecenttechnologiestotreatcarcinomasintheTheideaoflungdrugtargetingcamethereforeasanlungsconsistsindeliveringdrugsthroughthepulmonaryapplicationoftheexperiencesgainedfrommagneticdrugpathwaysdirectlytothetumorcellsoveractivelyloadedtargetinginthebloodvesselstoassurealoca
4、ltreatmentofsuperparamagneticnanoparticlesthatareencapsulatedinpulmonarydiseases[6].Thisnewtechniqueisconsideredtoaerosolsandguidedbyexternalmagneticfields.However,firstimplementationsofthistechniqueassumedahaveagreatpotential,especiallyforcancertherapy.continuousapplicationofthemagneticfieldallthro
5、ughtheHereby,adrugsolutionisnebulisedandmixedwithinspirationandexpirationphasesoftheartificialrespiratorybiocompatiblycoatedmagneticnanoparticlestoformactthatsuppliesthepatient.aerosoldropletsthatcanbecomemagnetizedandthereforeWeobservedthatapplyingthefieldthiswayforcedthebesteeredthroughexternalmag
6、neticsources,obeyingtomagneticaerosolstosedimentatregionsfarfromthetarget,thefollowingrule:mainlyinthetracheaandmainbronchioles,becauseoftheforceinducingmagneticfieldgradientsthatarepresentoverthewholefieldapplicationarea.Wedevelopedanapproachtoavoidthiseffectbypunctuallygeneratingtheaerosolcloudexa
7、ctlyattheWhereµisthemagneticmomentoftheaerosolandBisbeginningoftheinspirationphase,whichwouldpropelthethefluxdensityofthemagneticfield.particlestothedeepestpartsofthelungandthereforetotheThus,theprese
