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1、HZPPOCAMPUS,VOL.3,NO.3,PAGES317-3303JULY1993PhaseRelationshipBetweenHippocampalPlaceUnitsandtheEEGThetaRhythmJohnO'KeefeandMichaelL.RecceDepartmentofAnatomyandDevelopmentalBiology,UniversityCollegeLondon,London,U.K.ABSTRACTManycomplexspikecellsinthehippocampusofthefree
2、lymovingrathaveastheirprimarycorrelatetheanimal'slocationinanenvironment(placecells).Incontrast,thehippocampalelectroencephalographthetapatternofrhythmicalwaves(7-12Hz)isbettercorrelatedwithaclassofmovementsthatchangetherat'slocationinanenvironment.Duringmovementthroug
3、htheplacefield,thecomplexspikecellsoftenfireinaburstingpatternwithaninterburstfrequencyinthesamerangeastheconcurrentelectroencephalographtheta.Thepresentstudyexaminedthephaseofthethetawaveatwhichtheplacecellsfired.Itwasfoundthatfiringconsistentlybeganataparticularphase
4、astheratenteredthefieldbutthenshiftedinasystematicwayduringtraversalofthefield,movingprogressivelyforwardoneachthetacycle.Thisprecessionofthephaserangedfrom100"to3.55"indifferentcells.Theeffectappearedtobeduetothefactthatindividualcellshadahigherinterburstratethantheth
5、etafrequency.Thephasewashighlycorrelatedwithspatiallocationandlesswellcorrelatedwithtemporalaspectsofbehavior,suchasthetimeafterplacefieldentry.Theseresultshaveimplicationsforseveralaspectsofhippocampalfunction.First,byusingthephaserelationshipaswellasthefiringrate,pla
6、cecellscanimprovetheaccuracyofplacecoding.Second,thecharacteristicsofthephaseshiftconstrainthemodelsthatdefinetheconstructionofplacefields.Third,theresultsrestrictthetemporalandspatialcircumstancesunderwhichsynapsesinthehippocampuscouldbemodified.Keywords:placeunits,th
7、eta,phasecorrelatesTwoprincipaltypesofunitcanberecordedfromthepyra-isusuallyexaminedinthetimedomain.Ingeneral,themidalcelllayersoftherathippocampus:complexspikecellshippocampalEEGcanbedividedintotwomajorclasses:andthetacells(Ranck,1973;FoxandRanck,1975).Thepri-theta,wh
8、ichconsistsofsinusoidal7-12Hzwaves,andlargemarycorrelateofthefirstunitistheanimal'slocationinanirregularactivity,inwh
