资源描述：
《Genetic and Environmental Influences on Regional BrainUptake of 18F-FDG A PET Study on Monozygoticand Dizygotic Twins遗传和环境对区域脑的影响 18F-FDG摄取：单合子的PET研究 双卵双胎》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、Downloadedfromjnm.snmjournals.orgbySNMheadquartersonMarch1,2016.Forpersonaluseonly.GeneticandEnvironmentalInfluencesonRegionalBrainUptakeof18F-FDG:APETStudyonMonozygoticandDizygoticTwinsShinichiroWatanabe*1,HirokiKato*1,EkuShimosegawa1,2,andJunHatazawa1,31DepartmentofNuclearMedicineandTracerKin
2、etics,OsakaUniversityGraduateSchoolofMedicine,Osaka,Japan;2DepartmentofMolecularImaginginMedicine,OsakaUniversityGraduateSchoolofMedicine,Osaka,Japan;and3CenterforTwinResearch,OsakaUniversityGraduateSchoolofMedicine,Osaka,JapanrelatedchangesduringdevelopmentandagingandsexdifferencesGeneticoren
3、vironmentalinfluencesoncerebralglucosemetabo-inbrainglucosemetabolismhavebeenreported(3–7).Therest-lismareunknown.Weattemptedtorevealtheseinfluencesining-statemetabolicnetworkhasbeenexaminedinhealthyvolun-elderlytwinsbymeansof18F-FDGPET.Methods:18F-FDGuptaketeers(8–10).However,factorsinfluencingv
4、ariationsincerebralwasstudiedin40monozygoticand18dizygoticvolunteertwinpairsmetabolismitselfhavenotbeenpreciselyinvestigatedyet.Theaged30yorover.Wealsocreated18controlpairsbypairingage-patternsofglucosemetabolisminthebrainappeartobeinflu-andsex-matchedgeneticallyunrelatedsubjectsfromdizygotican
5、dencedbyvariousfactors,includinggeneticandenvironmentalmonozygoticpairs.SUVimagesofthebrainwerereconstructedfactors.However,themagnitudeandproportionoftheseinflu-andanalyzedbyvoxel-basedstatisticalanalysiswithautomated18encesremainunknown.region-of-interestsetting.TheF-FDGuptakeineachcerebrallo
6、bewassemiquantifiedbytakingaratioofSUVmeanineachregionofThetwinmethodhasbeenusedtoestimatetheextentofgeneticinteresttowhole-brainSUVaverage.Wecalculatedanintraclasscor-andenvironmentalinfluenceonassociationsamongmultiplerelationcoefficientofSUVratioineachregionofinterestformono-observedvariables(
7、11).Althoughthetwinmethodhasbeenusedzygoticanddizygoticpairs.Bycomparingdifferencesincoefficientsmainlyinthefieldofbehavioralgenetics,itisalsoapplicabletobetweenmonozygoticanddizygoticpairs,geneticandenvironmen-nonbehavioraltraits.Twinsar
