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1、BIOLOGYOFBREASTPRENEOPLASIAR.D.CARDIFF,MD,PHD,*S.R.WELLING,MD,PHD*ANDL.J.FAULKIN,PHD~Theliteraturedealingwithmammarycancerandthepresenceoftheidenti-fiablepreneoplasticlesionsinthemammaryglandofseveralspecieshasbeenreviewed.Adiscretemorphologicallyidentifiablelesi
2、onwithahighmalignantpotentialisconsideredpreneoplastic.Lobuloalveolarlesionshavebeenidenti-fiedinthehumanmammaryglandwhichfitmostofthecriteriaforpre-neoplasia.Thelesions,hyperplasticatypicallobules,aremulticentric,haveahighstatisticalassociationwithbreastcanceran
3、ddemonstrateamorphologicalprogressionthroughdysplasiatofrankcarcinoma.Otherbreastlesionshaveahighstatisticalassociationbutnomorphologicalprogressioncanbeseenandtheirneoplasticpotentialremainsunknown.Thesignificanceofthesecorrela-tionsisenhancedbytheoccurrenceofho
4、mologousbreastlesionsinoutbredandinbredanimalmodels.Statisticalcorrelationwithbreastcancerandaber-rantmorphologyhasbeenacceptedaspresumptiveevidenceofpreneoplasiainsomeanimals.Definitiveproofoftheneoplasticpotentialhasbeenobtainedinrodentmodelsbytransplantationof
5、thesuspectedlesionsandtheirsubsequentdevelopmentintocancers.Althoughastrongmorphologicalandstatisticalanalogyexistsbetweenthehumanandanimalmodels,thecausesandbiologicalpotentialofthehumanlesionsawaitexperimentalproof.Cancer39:2734-2746,1977.PRENEOPLASIAMAYBEDEFIN
6、EDASAMORPHO-andthuscanbearrangedinanarbitrarymor-logicallyidentifiablelesionwithahighriskphologiccontinuumfromnormaltocarcinomaofdevelopingintomalignancy.Suspectedpre-insitu.Thebiologicalbehavioroftheindividualneoplasticbreastlesionshavebeendescribedinlesionmustb
7、etheultimatecriterion.Tech-inbredpopulations(e.g.,mouseandrat)andniqueshavebeendevelopedtoassessthebiologi-outbredpopulations(e.g.,dog,monkeyandcalpotentialofindividuallesionsininbredro-man).Inallcasesthelesionsaredistinctivedentpopulationsand,therefore,mostofour
8、becausetheyarehyperplasticorproliferativeknowledgeofthebiologyofbreatpreneoplasiafociwhichstandoutfromthebackgroundofthecomesfromtheseexperimentalmodels.Simila
