[Nanophotonics] Aptamer-assembled nanomaterials for fluorescent sensing and imaging用于荧光的适体组装纳米材料 传感与成像

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1、Nanophotonics2017;6(1):109–121ReviewarticleOpenAccessDanqingLu,LeiHe,GeZhang,AipingLv,RuowenWang,XiaobingZhangandWeihongTan*Aptamer-assemblednanomaterialsforfluorescentsensingandimagingDOI10.1515/nanoph-2015-0145Keywords:aptamer;bioimaging;biosensing;cancerReceivedNovem

2、ber22,2015;revisedFebruary29,2016;acceptedtherapy;diseasediagnosis;drugdelivery;nanomaterials;March17,2016self-assembly.Abstract:Aptamers,whichareselectedinvitrobyatech-nologyknownasthesystematicevolutionofligandsbyexponentialenrichment(SELEX),representacrucialrec-1Intr

3、oductionognitionelementinmolecularsensing.Withadvantagessuchasgoodbiocompatibility,facilefunctionalization,Fluorescentbiosensingisapowerfultoolfordetectingbio-andspecialopticalandphysicalproperties,variousnano-logicallyrelevantmorphologicaldetailsaswellasmoni-materialsc

4、anprotectaptamersfromenzymaticdegrada-toringvariousphysiologicalprocessesinlivingsystems.Ittionandnonspecificbindinginlivingsystemsandthusisnoninvasive,highlysensitive,anddisposedtofastanal-provideapreeminentplatformforbiochemicalapplica-ysiswithspatialresolution.Assuch

5、,fluorescentbiosens-tions.Couplingaptamerswithvariousnanomaterialsingprovidesapromisingapproachtotheearlydiagnosisoffersmanyopportunitiesfordevelopinghighlysensi-ofseriousdiseasesaswellasinvivoquantitativemonitor-tiveandselectivesensingsystems.Here,wefocusontheingofdrug

6、release,andmanybiologicaltargetshavebeenrecentapplicationsofaptamer-assemblednanomaterialsidentifiedacrossawidespectrumofbiosciences.influorescentsensingandimaging.DifferenttypesofAptamersareshortsingle-strandedoligonucleotidesnanomaterialsareexaminedalongwiththeiradvan

7、tages(DNAorRNA)selectedfrom1012to1015combinatorialoli-anddisadvantages.Finally,welooktowardthefutureofgonucleotidelibrariesinvitrobythesystematicevolutionaptamer-assemblednanomaterials.ofligandsbyexponentialenrichment(SELEX)process.Byfoldingintodistinctsecondaryortertia

8、rystructures,aptamerscanbindtoavarietyoftargets,includingpep-tides,proteins,drugs,organicandinorganicmolecules