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1、Downloadedfromhttp://rsif.royalsocietypublishing.org/onAugust12,2018J.R.Soc.Interfacedoi:10.1098/rsif.2010.0680PublishedonlineNanostructuredglass–ceramiccoatingsfororthopaedicapplicationsGuochengWang1,ZufuLu1,XuanyongLiu2,XiamingZhou2,ChuanxianDing2andHa
2、laZreiqat1,*1BiomaterialsandTissueEngineeringResearchUnit,SchoolofAMME,UniversityofSydney,Sydney2006,Australia2ShanghaiInstituteofCeramics,ChineseAcademyofSciences,Shanghai200050,People’sRepublicofChinaGlass–ceramicshaveattractedmuchattentioninthebiomedi
3、calfield,astheyprovidegreatpossibilitiestomanipulatetheirpropertiesbypost-treatments,includingstrength,degra-dationrateandcoefficientofthermalexpansion.Inthiswork,hardystonite(HT;Ca2ZnSi2O7)andsphene(SP;CaTiSiO5)glass–ceramiccoatingswithnanostructureswerep
4、reparedbyaplasmaspraytechniqueusingconventionalpowders.ThebondingstrengthandVickershardnessforHTandSPcoatingsarehigherthanthereportedvaluesforplasma-sprayedhydroxyapatitecoatings.Bothtypesofcoatingsreleasebioactivecalcium(Ca)andsilicon(Si)ionsintothesurr
5、oundingenvironment.Mineralizationtestincell-freeculturemediumshowedthatmanymushroom-likeCaandphosphoruscompoundsformedontheHTcoatingsafter5h,suggestingitshighacellularmineralizationability.Primaryhumanosteoblastsattach,spreadandproliferatewellonbothtypes
6、ofcoatings.HigherproliferationratewasobservedontheHTcoatingscomparedwiththeSPcoatingsanduncoatedTi-6Al-4Valloy,probablyduetothezincionsreleasedfromtheHTcoatings.HigherexpressionlevelsofRunx2,osteopontinandtypeIcollagenwereobservedonbothtypesofcoatingscom
7、paredwithTi-6Al-4Valloy,possiblyduetotheCaandSireleasedfromthecoatings.ResultsofthisstudypointtothepotentialuseofHTandSPcoatingsfororthopaedicapplications.Keywords:plasmaspray;orthopaedic;titaniumalloy;nanostructure;osteogenicgenes;glass–ceramic1.INTRODU
8、CTIONfavourableforbonefixation[5].Plasma-sprayedhydro-xyapatite(HAp)coatingshavebeencommercializedTitaniumalloy(Ti-6Al-4V)iswidelyusedinortho-andwidelyusedinhipjointreplacementsowingtopaedicapplicationsincludingartificialhip
