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《Effects of Dose and Session Duration on CocaineSelf-Administration in Rats剂量和持续时间对可卡因的影响 大鼠自我给药》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、0022-3565/07/3203-1134–1143$20.00THEJOURNALOFPHARMACOLOGYANDEXPERIMENTALTHERAPEUTICSVol.320,No.3Copyright©2007byTheAmericanSocietyforPharmacologyandExperimentalTherapeutics113340/3185943JPET320:1134–1143,2007PrintedinU.S.A.EffectsofDoseandSessionDurationonCocain
2、eSelf-AdministrationinRatsSunmeeWee,SheilaE.Specio,andGeorgeF.KoobCommitteeontheNeurobiologyofAddictiveDisorders,theScrippsResearchInstitute,LaJolla,CaliforniaReceivedAugust31,2006;acceptedDecember27,2006ABSTRACTDownloadedfromPreviousstudiesshowedthatanextended6
3、-hsessiondurationInShArats,thecocainedose-responsefunctionwashigherinproducedanincreasingrateofcocaineself-administrationinratsatthetwohigherunitdosesthanatthelowerdoses.rats.ThepresentstudyfurtherinvestigatedtheeffectofdoseCocaineself-administrationincreasedin6
4、-and12-hsessions,andsessiondurationoncocaineself-administration.Eightbutnotin1-and3-hsessions.Theincreaseinself-administra-groupsofrats(4doses2sessiondurations)self-adminis-tionwasfasterandgreaterin12-hsessionsthan6-hsessions.teredoneoffourcocainedoses(0.25,0.5
5、,1,and2mg/kg/Thedatasuggestthatcocaineself-administrationincreasesatinjection)ineither1-or6-hsessionsunderafixed-ratiosched-variousdoseswithprolongedaccessandthatanincreaseinjpet.aspetjournals.orgule.Inanotherexperiment,twoothergroupsofratsself-therateofrespondi
6、ngispositivelyandinverselyassociatedadministered0.5mg/kg/injectionofcocaineineither3-or12-hwithsessiondurationandunitdose,respectively.Resultsalsosessions.Cocaineself-administrationincreasedatalldosesinimplythatcocaineintakereachesaceilingfasterathighdoses6-hses
7、sionsbutnotin1-hsessions.Cocaineintake(milligram/evenundershortsessionduration.Therefore,highdosesorkilogram)reachedanasymptoteearlieratahigherdose,buttheprolongedaccesstococainearemorelikelytoresultinarateofrespondingincreasedfasterwhenthedosewaslower.patternof
8、cocaineintakethatreflectscompulsiveuse.atASPETJournalsonAugust11,2018Drugself-administrationinlaboratoryanimalshasbeenstablelevelofself-administrationcanbemaintainedo
