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《Animal Models for Evaluation of BoneImplants and Devices Comparative BoneStructure and Common Model Uses骨评价的动物模型 植入物与装置：比较骨 结构与通用模型的使用》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、ReviewVeterinaryPathology2015,Vol.52(5)842-850AnimalModelsforEvaluationofBoneªTheAuthor(s)2015Reprintsandpermission:ImplantsandDevices:ComparativeBonesagepub.com/journalsPermissions.navDOI:10.1177/0300985815593124vet.sagepub.comStructureandCommonModelUses1L.M.WancketAbstractBoneimplantsandd
2、evicesarearapidlygrowingfieldwithinbiomedicalresearch,andimplantshavethepotentialtosignificantlyimprovehumanandanimalhealth.Animalmodelsplayakeyroleininitialproductdevelopmentandareimportantcomponentsofnonclinicaldataincludedinapplicationsforregulatoryapproval.Pathologistsareincreasinglybei
3、ngaskedtoevaluatethesemodelsattheinitialdevelopmentalandnonclinicalbiocompatibilitytestingstages,anditisimportanttounderstandtherelativemeritsanddeficienciesofvariousspecieswhenevaluatinganewmaterialordevice.Thisarticlesummarizescharacteristicsofthemostcommonlyusedspeciesinstudiesofboneimpl
4、antmaterials,includingdetailedinformationabouttherelevanceofaparticularmodeltohumanbonephysiologyandpathology.Speciesreviewedincludemice,rats,rabbits,guineapigs,dogs,sheep,goats,andnonhumanprimates.Ultimately,acomprehensiveunderstandingofthebenefitsandlimitationsofdifferentmodelspecieswilla
5、idinrigorouslyevaluatinganovelboneimplantmaterialordevice.Keywordsanimalmodels;biocompatibility;boneimplants;boneremodeling;dentalimplants;medicaldevice;peri-implantitis;safetyassess-mentBoneandjointimplantsanddevicesarearapidlygrowinglocalandsystemichostresponses.Toevaluatebothintendedport
6、ionofthehealthcareindustry,withanestimated$9billionandunintendedeffects,severalstagesareusedtoevaluateinMedicareexpendituresspentonimplantableorthopedicimplants,includingbiologicalrelevance,biofunctionality,bio-17devicesin2009.Considerableresearchcontinuestowardcompatibility/safety,andclini
7、calrelevance/efficacy.developingnoveldevicestoimproveboneandjointfunctionandhealth.Theimplantanddevicefieldcontainsdiverseclasses,includingtissue-engineeredconstructs,combinationBiologicalRelevanceproducts(ie,antimicrobialcoatingsfordevices),andbiomater-
