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1、TopologicalDeterminantsandConsequencesofAdventitialResponsestoArterialWallInjuryJean-BaptisteMichel,OlivierThaunat,XavierHouard,OlivierMeilhac,GiuseppinaCaligiuri,AntoninoNicolettiAbstractArteriesarecomposedof3concentrictissuelayerswhichexhibitdifferentstructuresandproperties.Bec
2、ausearterialinjuryisgenerallyinitiatedattheinterfacewithcirculatingblood,moststudiesperformedtounravelthemechanismsinvolvedininjury-inducedarterialresponseshavefocusedontheinnermostlayer(intima)ratherthanontheoutermostadventitiallayer.Inthepresentreview,wefocusontheinvolvementoft
3、headventitiainresponsetovarioustypesofarterialinjuryleadingtovascularremodeling.Physiologically,solublevascularmediatorsarecentrifugallyconveyedbymasstransporttowardtheadventitia.Moreover,inpathologicalconditions,neomediatorsandantigenscanbegeneratedwithinthearterialwall,whoseout
4、wardconveyancetriggersdifferentpatternsoflocaladventitialresponse.Adventitialangiogenesis,immunoinflammation,andfibrosissequentiallyinteractandtheirnetbalancedefinestheparticipationoftheadventitialresponseinarterialpathology.Inthepresentreviewwediscuss4pathologicalentitiesinwhich
5、theadventitialresponsetoarterialwallinjuryparticipatesinarterialwallremodeling.Hence,theadventitialadaptiveimmuneresponsepredominatesinchronicrejection.Inflammatoryphagocyticcellrecruitmentandinitiationofashiftfrominnatetoadaptiveimmunitycharacterizetheadventitialresponsetoproduc
6、tsofproteolysisinabdominalaorticaneurysm.Adventitialsproutingofneovessels,leadingtointraplaquehemorrhages,predominatesinatherothrombosis.Adventitialfibrosischaracterizestheresponsetomechanicalstressandisresponsiblefortheconstrictiveremodelingofarterialsegmentsandinitiatinginterst
7、itialfibrosisinperivasculartissues.Theseadventitialevents,therefore,haveanimpactnotonlyonthevesselwallbiologybutalsoonthesurroundingtissue.(ArteriosclerThrombVascBiol.2007;27:1259-1268.)KeyWords:masstransportangiogenesislymphoidneogenesischronicrejectionDownloadedfromhttp://ah
8、ajournals.orgbyonAugust6,2018abdominala
