The systemic toxicity of heavy metal mixtures in重金属混合物的系统毒性 胡扯

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1、ToxicologyResearchViewArticleOnlinePAPERViewJournal

2、ViewIssueThesystemictoxicityofheavymetalmixturesinratsCitethis:Toxicol.Res.,2018,7,396aaabaSamuelSelormFiatiKenston,†HongSu,†ZhouLi,†LuKong,YafeiWang,aaccaXinSong,YuanliangGu,TabathaBarber,JoniAldinger,QihangHua,aca,

3、ca,dZhenLi,MinDing,JinshunZhao*andXialuLin*Toexplorethehealtheffectsofmulti-heavymetalexposure,SpragueDawley(SD)ratswereorallygivenonedoseofheavymetalmixtures(HMMs).TheeightmostcommondetectableheavymetalsinNingboareaarezinc(Zn),copper(Cu),manganese(Mn),chromium(Cr),nic

4、kel(Ni),cadmium(Cd),lead(Pb)andmercury(Hg).Inthisstudy,mixturesoftheseeightheavymetalswerepreparedusingthecompoundszincsulfateheptahydrate,cupricsulfate,manganesedichloride,potassiumdichromate,nickeldichloride,cadmiumdichloride,leadacetate,andmethylmercurychloridewith

5、ionmassproportionsof1070.0,312.6,173.1,82.6,30.0,13.3,6.6,and1.0,respectively.Theratswererandomlydividedintofourgroups.CreativeCommonsAttribution-NonCommercial3.0UnportedLicence.Besidethecontrolgroup,eachratreceivedacorrespondingdoseofHMMs215,464or1000mgperkgbodyweigh

6、t(bwt),respectively.Theratswereobservedfor4weeks.Duringthelastweekofobservation,theMorriswatermazetestwasusedtoinvestigatespatiallearningandmemoryinthetreatedrats.Theratswereexsanguinatedundercompletechloralhydrateanesthesiaandorgancoefficientsweremeasured.Biochemicalte

7、stsofbloodandserumsampleswerecarriedout.TheresultsshowedReceived29thSeptember2017,abnormalitiesinthehematologicalsystem,decreasedrenalfunction,hepaticinjuryanddisturbancesinAccepted14thDecember2017theelectrolytebalanceoftheratstreatedwithahighdoseofHMMs.Deathofsomerat

8、swasalsoDOI:10.1039/c7tx00260bobserved.Thispaperanalyzedhowaone-timehighdoseoraladministrationofHMMsinducedsystemicThisarticleislicensedunderarsc.li/toxicology-researchtoxicity.OpenAccessArticle.Publishedon29January2018.Downloadedon8/6/201810:06:06AM.1.Introductionthr

9、oughwastedisposalmachineriesintheformofmetalfumesofsuspendedparticulates.SometraceamountsofheavyHeavymetalsarehighdensityele