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1、EvolutionaryApplicationsEvolutionaryApplicationsISSN1752-4571ORIGINALARTICLEAnewheterogeneousfamilyoftelomericallyencodedCryptosporidiumproteins11233MahaBouzid,PaulR.Hunter,VincentMcDonald,KristinElwin,RachelM.Chalmersand1,*KevinM.Tyler1BiomedicalResearchCentre,NorwichMedicalS
2、chool,UniversityofEastAngliaNorwich,UK2BartsandtheLondonSchoolofMedicineandDentistry,BlizardInstituteofCellandMolecularScience,CentreforDigestiveDiseasesLondon,UK3UKCryptosporidiumReferenceUnit,PublicHealthWales,Microbiology,SingletonHospitalSwansea,UKKeywordsAbstractbioinfoma
3、tics/phyloinfomatics,biomedicine,genomics/proteomics,hostparasiteCryptosporidiosisispredominantlycausedbytwocloselyrelatedspeciesofpro-interactions,microbialbiology,moleculartozoanparasitesthezoonoticCryptosporidiumparvumandanthroponoticCryp-evolution,parasitology,virulencetos
4、poridiumhominiswhichdivergephenotypicallyinrespecttohostrangeandvirulence.Usingcomparativegenomicsweidentifiedtwogenesdisplayingovert*Correspondenceheterogeneitybetweenspecies.AlthoughinitialworksuggestedbothwerespeciesKevinM.Tyler,BiomedicalResearchCentre,specific,Cops-1forC.pa
5、rvumandChos-1forC.hominis,subsequentstudyiden-NorwichMedicalSchool,UniversityofEasttifiedanabridgedorthologofCops-1inC.hominis.Cops-1andChos-1showedAnglia,NorwichNR47TJ,UK.Tel.:+44(0)1603591225;limited,butsignificant,similaritytoeachotherandsharecommonfeatures:(i)fax:+44(0)16035
6、91750;telomericlocation:Cops-1isthelastgeneonchromosome2,whilstChos-1isthee-mail:K.Tyler@uea.ac.ukfirstgeneonchromosome5,(ii)encodecirca50-kDasecretedproteinswithiso-electricpointsabove10,(iii)areserinerich,and(iv)containinternalnucleotideReceived:30April2012repeats.Importantly
7、,Cops-1sequencecontainsspecificSNPswithgooddiscrimi-Accepted:2May2012natorypowerusefulepidemiologically.C.parvum-infectedpatientserarecog-nizeda50-kDaproteininantigenpreparationsofC.parvumbutnotC.hominis,doi:10.1111/j.1752-4571.2012.00277.xconsistentwithCops-1beingantigenicforp
8、atients.Interestingly,anti-Cops-1monoclonalantibody(9E1)stain
