遗传学与分子生物学系

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1、遗传学与分子生物学系MolucularBiologyLuShermin(吕社民)Tel:82657764Email:lushemin@mail.xjtu.edu.cn遗传学与分子生物学系LectureI:IntroductionOfMolecularBiologyDefinition,GoalandScopeFundamentalsAbriefhistoryMethodologyofMolecularBiologyRoleinMedicalsciencesprospective遗传学与分子生物学系Definition

2、Anelusiveterm,MorethanonedefinitionStudylife(biology)inmolecularlevelStudygenestructureandfunctionatthemolecularlevel.Grewoutofthedisciplinesofgeneticsandbiochemistry.HybriddisciplineBiochemistryGeneticsMolecularBiologyBiophysics遗传学与分子生物学系GoalTounderstandthe

3、fivebasiccellbehaviorpatterns(growth,division,specialization,movement,andinteraction)intermsofvariousmoleculesthatareresponsibleforthem遗传学与分子生物学系ScopeStructureandfunctionofNucleotidesandproteinStructureandfunctionofgenomeGeneproliferation,expression,regulationa

4、ndbiologicalfunctionInteractionbetweenbiologicalmacromoleculesIntraandintermolecularsignaltransductionTechnologyofmolecularbiology遗传学与分子生物学系ScopeofMedicalMolecularBiologyMolecularmechanismofcellulargrowth,differentiationandSenescenceinhumanbeingMolecularbasisof

5、proliferationanditsregulationofhumancellsMolecularBiologyofthreeregulatorysystems(nervous,endocrineandimmunesystems)inhumanbodyRelationshipbetweenabnormalityofgenestructure,regulationwithetiopathogenesisofhumandiseasesGenediagnosisandgenetherapyintermsoftheorya

6、ndtechnologyofmolecularbiologyDrugdiscoveryandhealthcareintermsoftheoryandtechnologyofmolecularbiology遗传学与分子生物学系LectureI:IntroductionOfMolecularBiologyDefinition,GoalandScopeFundamentalsAbriefhistoryMethodologyofMolecularBiologyRoleinMedicalsciencesprospective遗

7、传学与分子生物学系遗传学与分子生物学系“Weak”InteractionsChemicalbonds(covalent)haveenergiesof~101->2kcal/mole.STRONGWeakinteractionsHydrogenbonds~5kcal/moleVanderWaalsinteractions~1kcal/mole“Hydrophobic”interactionsLessclassifiable,aconsequenceofotherforces遗传学与分子生物学系Hydrophobicin

8、teractionsPolarmaterials(water)onbalancehaveattractiveintermolecularforces.Nonpolarmaterialshavenoparticulartendencytoassociate.Result:Nonpolarmaterialswithinanaqueouscompar