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1、475BiomedicalScienceTreatmentofB-cellLymphomaUsingPeptidesANovelConceptKITS.LAM,MD,PhD,Tucson,ArizonaBasedonapaperpresentedattheannualmeetingoftheWesternAssociationofPhysicians,Cannel,California,February5-6,1992.Combinationchemotherapyremainsthemajorcurrenttreatm
2、entofnon-Hodgkin'slymphoma.B-celllymphomaoftenhastumor-specificsurfaceimmunoglobulinscalledidiotypes.Clinicaltrialsusingmurinemonoclonalanti-idiotypeantibodiesasatargetingapproachhaveshownsomesuccess.Idescribeanovelconceptofusingidiotype-specificpeptidesasanalter
3、nativetargetingapproachforthetreatmentofB-celllymphoma.Inbrief,octapeptidesthatbindtothesurfaceidiotypeoftheB-celllymphomaareisolatedfromalargesyntheticpeptidelibrary(106to107peptides).Oncethesequenceofatumor-specificoctapeptideligandisdefined,largequantitiescanb
4、esynthesizedandconjugatedwitharadionuclide(suchasiodine131).Thisshouldpermithighlyspecificdestruc-tionoflymphomacellsthatbindthelabeledpeptide.Thetheoreticadvantagesofthisapproachovertheprevioususeofanti-idiotypeantibodiesareaddressed.(LamKS:TreatmentofB-celllymp
5、homausingpeptides-Anovelconcept.WestJMed1993May;158:475-479)Lymphoma,cancerofthelymphaticsystem,isclassi-fiedasHodgkin'sdiseaseandnon-Hodgkin'slym-TABLE1.-CurrentTreatmentOptionsforLymphomaphoma.Non-Hodgkin'slymphomaaccountsforaboutNotreatment3%to5%ofthedeathsfro
6、mallhumanmalignantneo-Conventionalchemotherapyplasms.About35,000newcasesofthediseaseoccurRadiationtherapyeachyearintheUnitedStates.TheUSincidenceis10.2Biologictherapy,suchasinterferonalfaper100,000formenand7.5per100,000forwomen.Bonemarrowtransplantation,autologou
7、sBasedonmorphology,theNationalCancerInstitute'sMonoclonalantibody,suchasanti-idiotypeWorkingFormulationdividesnon-Hodgkin'slymphomaintothreegrades-low,intermediate,andhigh-withBiologictherapysuchasinterferonalfamaybeusefulinfurthersubclassifications.'Thelow-grade
8、form,whichlow-gradelymphomas,2andautologousbonemarrowaccountsforabout40%ofallcases,isclassifiedas"in-transplantationmaybenefityoungerpatientswithrefrac-dolent"
