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1、ExperimentalandMolecularPathology97(2014)74–80ContentslistsavailableatScienceDirectExperimentalandMolecularPathologyjournalhomepage:www.elsevier.com/locate/yexmpSineoculishomeoboxhomolog1proteinasanindependentbiomarkerforgastricadenocarcinomaa,c,1b,1ccdb,⁎,ZhenhuaLina,c,⁎⁎HuixinLv,Ail
2、iCui,FengdanSun,YuanZhang,YanLi,LianhuaLiaKeyLaboratoryofNaturalResourcesofChangbaiMountain&FunctionalMolecules,YanbianUniversity,MinistryofEducation,Yanji133002,ChinabDepartmentofDermatology,YanbianUniversityHospital,Yanji133000,ChinacDepartmentofPathology,YanbianUniversityMedicalCol
3、lege,Yanji133002,ChinadDepartmentofPathology,LuheTeachingHospitaloftheCapitalMedicalUniversity,Beijing101100,ChinaarticleinfoabstractArticlehistory:Sineoculishomeoboxhomolog1(SIX1)proteinisamemberofthehomeoboxtranscriptionfactorfamily.Received24January2014OverexpressionofSIX1contribut
4、estocancerprogressionandisassociatedwithadverseoutcomesinvariouscancerandinrevisedform19May2014typesincludingbreast,ovarian,uterinecervicalandliver.ToinvestigatetheclinicopathologicalsignificanceofSIX1Availableonline24May2014proteinexpressioningastricadenocarcinomas(GAC),localizationof
5、theSIX1proteinwasdeterminedinMKN-1,agastriccancercellline,usingimmunofluorescence(IF)staining;SIX1mRNAlevelwasdetectedinfreshtissuesofKeywords:GACandnormalgastricmucosausingquantitativereal-timepolymerasechainreaction(qRT-PCR);andSIX1proteinGastriccancerSIX1expressionwasassessedin163GA
6、C,35gastricdysplasiaand26normalgastricmucosausingimmunohistochemicalPrognosis(IHC)staining.CorrelationsbetweenSIX1proteinexpressionandpathologicalparametersofGACwereanalyzedSurvivalanalysisusingChi-squaretests,differencesinsurvivalcurveswereanalyzedusinglog-ranktests,andmultivariatesu
7、rvivalanalysiswasperformedusingtheCoxproportionalhazardsregressionmodel.SIX1proteinshowedamainlycytoplasmicstainingpatterninGACusingIFandIHCstaining.ThepositiveSIX1proteinexpressionratewas80.4%inGAC,whichwassignificantlyhigherthanineithergastricdysplasia(45.7%)ornormalgastricmucosa(26.
8、9%)(P
