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1、JournalofEthnopharmacology143(2012)448–454ContentslistsavailableatSciVerseScienceDirectJournalofEthnopharmacologyjournalhomepage:www.elsevier.com/locate/jepProtectiverolesofCordycepsonlungfibrosisincellularandratmodelsa,bacdaeMengliChen,FlorenceW.K.Cheung,MingHungChan,PakKwanHui,Siu-PoI
2、p,YickHinLing,a,f,ne,nnChun-TaoChe,WingKeungLiuaSchoolofChineseMedicine,TheChineseUniversityofHongKong,Shatin,HongKongbDepartmentofClinicalPharmacology,GeneralHospitalofPLA,Beijing,ChinacDepartmentofMedicine,KwongWahHospital,TheTungWahGroupofHospitals,Kowloon,HongKongdDepartmentofPatho
3、logy,KwongWahHospital,TheTungWahGroupofHospitals,Kowloon,HongKongeSchoolofBiomedicalSciences,FacultyofMedicine,TheChineseUniversityofHongKong,Shatin,HongKongfDepartmentofMedicinalChemistryandPharmacognosy,CollegeofPharmacy,UniversityofIllinoisatChicago,Chicago,Illinois,IL60612,USAartic
4、leinfoabstractArticlehistory:Ethnopharmacologicalrelevance:CordycepssinensisisafungususedintraditionalChinesemedicineasaReceived23November2011tonictosoothethelungforthetreatmentoffatigueandrespiratorydiseases.ReceivedinrevisedformIdiopathicpulmonaryfibrosisisachronic,irreversibleanddebi
5、litatinglungdiseaseshowing11June2012fibroblast/myofibroblastexpansionandexcessivedepositionofextracellularmatrixintheinterstitiumAccepted19June2012leadingtobreathingdifficulty.OurpreviousobservationrevealedapartialreliefoflungfibrosisinAvailableonline13July2012patientssufferingfromsevereac
6、uterespiratorysyndrome(SARS).WehypothesizethatCordycepshasKeywords:beneficialeffectsonlungfibrosisandtheobjectiveofthisstudyistoexplorethetarget(s)ofCordycepsCordycepssinensisinthereliefoflungfibrosisinanimalandcellmodelsandtogaininsightintoitsunderlyingCordycepinmechanisms.Bleomycin-indu
7、cedlungfibrosisMaterialandmethods:Aratmodelofbleomycin(BLM)-inducedlungfibrosisandafibroticcellmodelTraditionalChinesemedicinewithtransforminggrowthfactorbeta-1inductionwereemployedinthestudies.Results:Reductionofinfiltrationofinflammatorycells,depositionoffibroblasticlociandcollagen,forma
