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1、ArchMicrobiol(2001)176:237–242DOI10.1007/s002030100321MINI-REVIEWPascaleServant·PhilippeMazodierNegativeregulationoftheheatshockresponseinStreptomycesReceived:21March2001/Revised:23May2001/Accepted:3June2001/Publishedonline:11July2001©Springer-Verlag2001AbstractAllorganismsrespond
2、toasuddenincreaseincalledheatshockproteins(HSPs).HSPsincludemolecu-temperaturebyinducingthesynthesisofasetofproteinslarchaperonesinvolvedinthecorrectfoldingofnewlycalledheatshockproteins(HSPs).Althoughtheinductionsynthesizedanddenaturedproteins,inassemblyandinofHSPsisauniversalres
3、ponse,adiversityofmecha-thetransportofotherproteins.OthermembersofthisnismscontrolHSPsynthesisindifferentorganisms.Ingrouphaveproteolyticactivity(GeorgopoulosandWelchStreptomyces,thesynthesisofmajorHSPs,suchasthe1993;Gottesmanetal.1997;HendrickandHartl1993).widespreadmolecularchap
4、eronesDnaK,ClpB,GroELTheseproteinsareessentialfornormalgrowth,buttheirandHSP18,isnegativelycontrolledatthetranscriptionalcatalyticactivitiesareparticularlyimportantinstresscon-levelbyatleastthreedifferentrepressors.Thecontrolofditions,whichleadtotheaccumulationofunfoldedorin-groEg
5、eneexpressioninvolvesaninvertedrepeat(calledcorrectlyfoldedproteins.AlthoughtheinductionofHSPstheCIRCEelement)thatishighlyconservedamongeu-isauniversalresponse,theregulatorymechanismscon-bacteria,andtheHrcArepressor.ThednaKoperonandtrollingHSPsynthesisdifferwidelybetweenorganisms.
6、clpBbelongtotheHspR/HAIRregulon.TheHspRre-Bacteriaregulatethetranscriptionofheatshockgenesbypressor-HAIRoperatorsystemisusedinsomebacteriameansofbothpositiveandnegativemechanisms.Thebutisnotwidespread.Inparticular,ithasnotbeenfoundregulationoftheheatshockresponsewasfirststudiedini
7、ngram-positivebacteriawithlowG+Ccontent.Tran-Escherichiacoli.Thisbacteriumdisplayspositiveregula-scriptionofhsp18,whichencodesasmallHSP,isregu-tiondependingonthelevelandactivityofspecificsigmalatedbytheRheArepressor.Thisrepressor,whichhasin-factors,s32ands24(forreviewsseeBukau1993
8、;Yuraettrinsicthermosensoractivit
