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1、letterstonature14.Zhang,K.etal.Structure,alternativesplicing,andexpressionofthehumanRGS9gene.Gene240,isolatedbyfluorescence-activatedcellsorting(FACS)fromadult23–34(1999).brainscanproliferate,self-renewanddifferentiateintoallneural15.Rahman,Z.etal.Cloningandcharacterizationof
2、RGS9-2:Astriatal-enrichedalternativelysplicedproductoftheRGS9gene.JNeurosci.19,2016–2026(1999).celltypesinvitro.Bycontrast,TLX-nullcellsisolatedfromadult16.Kooijman,A.C.,Houtman,A.,Damhof,A.&vanEngelen,J.P.Prolongedelectro-retinalresponsemutantbrainsfailtoproliferate.Reintro
3、ducingTLXintoFACS-suppression(PERRS)inpatientswithstationarysubnormalvisualacuityandphotophobia.Doc.sortedTLX-nullcellsrescuestheirabilitytoproliferateandtoOphthalmol.78,245–254(1991).self-renew.Invivo,TLXmutantmiceshowalossofcellprolifer-17.Slep,K.C.etal.Structuraldetermina
4、ntsforregulationofphosphodiesterasebyaGproteinat2.0A˚.Nature409,1071–1077(2001).ationandreducedlabellingofnestininneurogenicareasinthe18.Sandberg,M.A.,Pawlyk,B.S.&Berson,E.L.Acuityrecoveryandconepigmentregenerationafteraadultbrain.TLXcansilenceglia-specificexpressionoftheblea
5、chinpatientswithretinitispigmentosaandrhodopsinmutations.Invest.Ophthalmol.Vis.Sci.40,astrocytemarkerGFAPinneuralstemcells,suggestingthat2457–2461(1999).transcriptionalrepressionmaybecrucialinmaintainingthe19.Berson,E.L.,Gouras,P.&Gunkel,R.D.Progressiveconedegeneration,domin
6、antlyinherited.Arch.Ophthalmol.80,77–83(1968).undifferentiatedstateofthesecells.20.Kooijman,A.C.etal.Spectralsensitivityfunctionofthea-waveofthehumanelectroretinograminExpressionofTLXinthemousestartsatembryonicday8(E8),thedark-adaptedeye.Clin.VisionSci.6,379–383(1991).peaksa
7、tE13.5anddecreasesbyE16,withbarelydetectablelevelsat21.Sandberg,M.A.etal.RodandconefunctionintheNougaretformofstationarynightblindness.Arch.birth.TLXexpressionincreasesafterbirthandishighintheadultOphthalmol.116,867–872(1998).322.Martemyanov,K.A.&Arshavsky,V.Y.Noncatalyticdo
8、mainsofRGS9-1·Gb5Lplayadecisiveroleinbrain.AlthoughTLX-nullmiceappeargrossl