资源描述：
《SHH Mediated Synergistic Effects Guiding Angiogenesis and Osteogenesis》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、CHAPTERTWENTY-TWOSonicHedgehog-MediatedSynergisticEffectsGuidingAngiogenesisandOsteogenesisSabineFuchs,EvaDohle,andCharlesJamesKirkpatrickContentsI.GeneralIntroduction492II.GeneralAspectsofShhSignaling492III.TheRoleofHhMorphogensinBoneDevelopmentandRepair493IV.Shh
2、:PotentialCandidateLinkingAngiogenesisandOsteogenesis494V.EffectsofShhonAngiogenesis,VesselMaturation,andOsteogenesis494VI.CocultureModelsasInVitroModelstoInvestigateEffectsofShhonOsteogenesisandAngiogenesis496VII.EffectsofShhonAngiogenesisinaCocultureModel497VIII
3、.EffectsofShhonOsteogenesisinaCocultureModel499IX.FutureTherapeuticalOptionsandDeliveryStrategies501References502AbstractSonichedgehog(Shh)isamorphogencontrollingtheskeletalandvasculardevelopmentintheembryobutisalsoreactivatedduringadultrepairpro-cesses.Thus,thism
4、oleculeholdsgreattherapeuticpotentialforbiotechnologi-calandbiomedicalapproachesaimingtoenhancetissueregenerationortoreplacedamagedtissues.Accordingtopresentknowledge,Shhsignalingcontrolstheexpressionofseveralfamiliesofgrowthfactorsinvolvedinneo-vascularizationand
5、vesselmaturationandactsupstreamofthemostprominentangiogenicgrowthfactor,vascularendothelialgrowthfactor.Inthiscontext,averyinterestingfeatureofShhisthatitcontrolsbothangiogenicactivityandvesselstabilizationbymuralcells.Inparallel,Shhseemstohaveadirecteffectonendot
6、helialcelltubeformationandseemstotriggerthedifferentiationprocessofmesenchymalstemcellstowardtheosteogeniclineage.Inthischapter,wewillthereforeshortlysummarizethemultifacetedpotentialofShhInstituteofPathology,Langenbeckstr.1,JohannesGutenbergUniversity,Mainz,Germa
7、nyVitaminsandHormones,Volume88#2012ElsevierInc.ISSN0083-6729,DOI:10.1016/B978-0-12-394622-5.00022-5Allrightsreserved.491492SabineFuchsetal.forbonerepairandvascularizationaccordingtothecurrentliterature.Inaddition,wewillshowhowcoculturemodelsbasedonoutgrowthendothe
8、lialcellsandprimaryosteoblastscanbeusedtorevealsomeoftherelevantmechanismsbywhichShhdrivesandconnectsboneregenerationandvascularization.ß2012ElsevierInc
