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1、TreatingDysbiosisByDr.NatashaWolf,BScHNDTheGISystemandMicrobiomeInteractionTheentiregastrointestinal(GI)systemplaysamassiveroleinhumanhealth,includingnutrientabsorption,wasteelimination,protectionagainstharmfulmicrobes,andprovidingahostenvironmentforsymbioticbacteria.Inturn,thecomposition
2、oftheGIsystemmicrofloraisanimportantfactorinthemaintenanceofnormalGIsystemfunctionandoverallhealth.Consistingof1014 bacteria1 andtypicallyweighingaroundthreepounds,theGIsystemmicrobiomecanbeviewedasanimportantmetabolicorgan.Whenfunctioningoptimally,ahealthymicrobiomesupportsproductionofce
3、rtainB-vitaminsandvitaminK2,3,enhancestheimmunesystem4,improvesgastrointestinalmotilityandtransittime5,increasesnutrientabsorption6,inhibitspathogenicorganisms3,isinvolvedinhormone 7 anddrugmetabolism8,andhelpstosupportthenormalfunctionofintestinalepithelialcells.DysbiosisAccordingtoprobi
4、oticresearcherDr.NigelPlummer,thenormalhumanmicrobiotaisthe“commensalmicrobialpopulationwhichresideswithinthehuman…whichisbothpersistentandstable,andwhichdoesnotelicitanacuteimmuneresponse”.Alterationstothenormalcompositionofthemicrobiomeareknownas“dysbiosis”9.Dysbiosistypicallyinvolvesde
5、creasedpopulationsofcommensalbacteriaandanovergrowthofpathogenicbacteria10.Thisresultsinimpairedintestinalfunction,andincreasedinflammationandimmunesensitization10,11.Dysbiosisisassociatedwithnumerouschronichealthconditionsincluding:GISystemDisorders§Irritableboweldisease(IBS)§Inflammator
6、yboweldisease(IBD)InflammatorySkinConditions§Eczema§Psoriasis§AcneTheEffectsofDysbiosisWhendysbiosisoccurs,thenormaltightjunctionsinhealthymucosalliningbecomeleakyandinflamed. DysbiosisisthereforeoneofthecausesoffoodsensitivitiesandGIinflammation,alsocalledleakygut. Leakygutsyndromeoccurs
7、whenbacteriaanddietaryantigensleakthroughthemucosalbarrier,causinginflammationinthelaminapropriaandincreasedintestinalpermeability.Dysbiosistriggersanabnormalimmuneresponseandresultsinanimbalanceofthecell-mediated(Th1)andantibody-mediated(Th2)immuneresponses12. TheT
