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1、QuantitativeEEGandElectromagneticBrainImaginginAgingandintheEvolutionofDementiaLESLIES.PRICHEPa,baBrainResearchLaboratories,DepartmentofPsychiatry,NewYorkUniversitySchoolofMedicine,NewYork,NewYork,USAbNathanS.KlineInstituteforPsychiatricResearch,NYSDepartmen
2、tofMentalHealth,Orangeburg,NewYork,USAABSTRACT:Electroencephalographic(EEG)changeswithnormalaginghavelongbeenreported.Departuresfromage-expectedchangeshavebeenobservedinmildcognitiveimpairmentanddementia,themagni-tudeofwhichcorrelateswiththedegreeofcognitive
3、impairment.Suchabnormalitiesincludeincreaseddeltaandthetaactivity,decreasedmeanfrequency,andchangesincoherence.Similarfindingshavebeenreportedusingmagnetoencephalography(MEG)atrestandduringperformanceofmentaltasks.Electrophysiologicalfeatureshavealsobeenshow
4、ntobepredictiveoffuturedeclineinmildcognitiveimpairment(MCI)andAlzheimer’sdisease(AD).Wehaverecentlyreportedresultsfrominitialquantitativeelectroencephalography(QEEG)evaluationsofnormalel-derlysubjects(withonlysubjectivereportsofmemoryloss),predictingfuturec
5、ognitivedeclineorconversiontodementia,withhighpredictionaccuracy(approximately95%).Inthisreport,sourcelocalizationalgo-rithmswereusedtoidentifythemathematicallymostprobableunder-lyinggeneratorsofabnormalfeaturesofthescalp-recordedEEGfromthesepatientswithdiff
6、erentialoutcomes.UsingthisQEEGmethod,ab-normalitiesinbrainregionsidentifiedinstudiesofADusingMEG,MRI,andpositronemissiontomography(PET)imagingwerefoundinthepre-morbidrecordingsofthosesubjectswhogoontodeclineorconverttodementia.KEYWORDS:electromagneticimaging
7、;QEEG;prediction;dementia;MCIINTRODUCTIONInformationderivedfrombrainelectricalactivityhascontributedtotheunderstandingofnormalbrainfunctionandtoabetterunderstandingofthepathophysiologyofbraindysfunctionseeninneuropsychiatricdisorders.BothAddressforcorrespond
8、ence:LesliePrichep,BrainResearchLaboratories,OldBellevueAdmin.Bldg.,8thFl.,462FirstAvenue,NewYork,NY10016.Voice:212-263-6288;fax:212-263-6457.leslie.prichep@med.nyu.eduAnn.N.Y.Acad.Sci.1097:156–
