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1、Homosapiensfms-relatedtyrosinekinase3(FLT3),RefSeqGeneonchromosome13NCBIReferenceSequence:NG_007066.1FASTA GraphicsLOCUSNG_007066104953bpDNAlinearPRI11-JUN-2012DEFINITIONHomosapiensfms-relatedtyrosinekinase3(FLT3),RefSeqGeneonchromosome13.ACCESSIONNG_007066VERSIONNG_007066
2、.1GI:160358346KEYWORDSRefSeqGene.SOURCEHomosapiens(human)ORGANISMHomosapiensEukaryota;Metazoa;Chordata;Craniata;Vertebrata;Euteleostomi;Mammalia;Eutheria;Euarchontoglires;Primates;Haplorrhini;Catarrhini;Hominidae;Homo.REFERENCE1(bases1to104953)AUTHORSParcells,B.W.,Ikeda,A.
3、K.,Simms-Waldrip,T.,Moore,T.B.andSakamoto,K.M.TITLEFMS-liketyrosinekinase3innormalhematopoiesisandacutemyeloidleukemiaJOURNALStemCells24(5),1174-1184(2006)PUBMED16410383REMARKReviewarticleCOMMENTREVIEWEDREFSEQ:ThisrecordhasbeencuratedbyNCBIstaffincollaborationwithRodDockin
4、g.ThereferencesequencewasderivedfromAL356915.19,AL445262.7andAL591024.14.ThissequenceisareferencestandardintheRefSeqGeneproject.Summary:ThisgeneencodesaclassIIIreceptortyrosinekinasethatregulateshematopoiesis.Thereceptorconsistsofanextracellulardomaincomposedoffiveimmunogl
5、obulin-likedomains,onetransmembraneregion,andacytoplasmickinasedomainsplitintotwopartsbyakinase-insertdomain.Thereceptorisactivatedbybindingofthefms-relatedtyrosinekinase3ligandtotheextracellulardomain,whichinduceshomodimerformationintheplasmamembraneleadingtoautophosphory
6、lationofthereceptor.Theactivatedreceptorkinasesubsequentlyphosphorylatesandactivatesmultiplecytoplasmiceffectormoleculesinpathwaysinvolvedinapoptosis,proliferation,anddifferentiationofhematopoieticcellsinbonemarrow.Mutationsthatresultintheconstitutiveactivationofthisrecept
7、orresultinacutemyeloidleukemiaandacutelymphoblasticleukemia.[providedbyRefSeq,Jul2008].PRIMARYREFSEQ_SPANPRIMARY_IDENTIFIERPRIMARY_SPANCOMP1-65701AL356915.19101-65801c65702-86823AL445262.72000-23121c86824-104953AL591024.1458592-76721cFEATURESLocation/Qualifierssource1..104
8、953/organism="Homosapiens"/mol_type="genomicDNA"/db_xref="taxon:9606"/chromosome="13"/map
