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1、TrialsBioMedCentralStudyprotocolOpenAccessNewtherapeuticapproachtoTouretteSyndromeinchildrenbasedonarandomizedplacebo-controlleddouble-blindphaseIVstudyoftheeffectivenessandsafetyofmagnesiumandvitaminB6RafaelGarcia-Lopez*1,EmilioPerea-Milla2,3,CesarRuizGarcia4,FranciscoRivas-Ruiz2,3,JulioRomero-
2、Gonzalez5,JoseLMoreno6,VicenteFaus6,GuadalupedelCastilloAguas7andJuanCRamosDiaz8Address:1DepartmentofAnaesthesiaandReanimation,HospitalCostadelSol,CtraNacional340,km187,29603Marbella,Spain,2ResearchSupportUnit,HospitalCostadelSol,CtraNacional340,km187,29603Marbella,Spain,3CIBEREpidemiologíaySalu
3、dPública(CIBERESP),Spain,4DepartmentofPaediatrics,HospitalCostadelSol,CtraNacional340,km187,29603Marbella,Spain,5DepartmentofPaediatrics,Children'sandMaternalHospitalinGranada,Av.FuerzasArmadasn°2,18014Granada,Spain,6DepartmentofPharmacy,HospitalCostadelSol,CtraNacional340,km187,29603Marbella,Sp
4、ain,7CSLaCarihuela,Torremolinos,Spainand8HospitaldeAntequera,Av.PoetaMuñozRojas,29200,Antequera,SpainEmail:RafaelGarcia-Lopez*-drgarcia.anest@telefonica.net;EmilioPerea-Milla-eperea@hcs.es;CesarRuizGarcia-cejutwo@hotmail.com;FranciscoRivas-Ruiz-frivasr@hcs.es;JulioRomero-Gonzalez-julio.romero.ss
5、pa@juntadeandalucia.es;JoseLMoreno-jlmharo@hcs.es;VicenteFaus-vfaus@hcs.es;GuadalupedelCastilloAguas-gdelcas@teleline.es;JuanCRamosDiaz-juancarlosramosdiaz@yahoo.es*CorrespondingauthorPublished:10March2009Received:15September2008Accepted:10March2009Trials2009,10:16doi:10.1186/1745-6215-10-16This
6、articleisavailablefrom:http://www.trialsjournal.com/content/10/1/16©2009Garcia-Lopezetal;licenseeBioMedCentralLtd.ThisisanOpenAccessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense(http://creativecommons.org/licenses/by/2.0),whichpermitsunrestricteduse,distribution,andreprod
7、uctioninanymedium,providedtheoriginalworkisproperlycited.AbstractBackground:TouretteSyndrome(TS)isaneurologicalconditionpresentingchronicmotorandphonictics,andimportantdegreeofcomorbidity.Consideredanuncommonillness,itfirstb
