Pharmacological strategies and micrometastasis what is known What mest be done

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1、MINERVAMED2010;101:163-78Pharmacologicalstrategiesandmicrometastasis:whatisknown?Whatmustbedone?G.Y.PERRETMetastasisaccountsforover90%ofcancerAPHP,AvicenneHospitalpatientdeaths.Inspiteofthis,themajorityofPharmacologyLaboratory,Bobigny,France®thecurrentlyuseddrugsareaimedateradica-tin

2、gorcontrollingtheprimarytumor.Hardlyanycancertherapiesusedatthemomentinter-fereonlywithmetastasisandthereisaneedfordrugsactingspecificallyonthemetastaticpro-cesses,curingtheminimalresidualdiseaseandthemomentinterfereonlywithmetastasis.beinglesstoxicthanthecurrentdrugs.Manytherapeutic

3、approachesforadvancedSearchingfordrugsthatdonotaffectthecancerstargetboththeprimarytumorandgrowthoftheprimarytumorbutinhibitthemetastasessimultaneouslybyblockingtumorcolonizationand/ortheoutgrowthindistantcellproliferationandsurvivalortumorvas-sitescouldleadtonewdrugsspecificallyaime

4、dcularization,whicharerequiredinbothset-attreatingtheminimalresidualdisease.Thetings.aimofthisworkistosearchatwhatcondi-tionssuchdrugsmightbediscoveredandifTheuseofthesedrugsisimplicitlybasedsomeexistalready.Forthat,mechanismsofontheassumptionthatthepropertiesoftheactionsofcurrentexp

5、erimentalandclinicalneoplasticcellsandtheirinteractionswithantimetastaticdrugsaredescribedandtheirthetumormicroenvironmentarenotfunda-utilityfordifferentclinicalsettings(primarymentallydifferentintheprimarytumorandprevention,adjuvantsetting)isanalyzed.Inthemetastaticsites.Thereforeth

6、eyaresup-conclusion,cluesexistthatspecificantimeta-staticdrugscouldexistandwillbedevelopedposedtobeequallyefficienttotreatthepri-inanearfuture.marytumorandtheminimalresidualdiseaseKeywords:MINERVAMEDICANeoplasmmetastasis-Neoplasm,afterremovaloftheprimarytumor.residual-Antineoplastica

7、gents.Unfortunately,thecurrentclinicalandexper-imentalevidencedoesnotsupportthisassumptionandthereisaneedfordrugsact-etastasisaccountsforover90%ofcan-COPYRIGHTingspecificallyonthemetastaticprocesses,Mcerpatientdeaths.Inspiteofthis,thecuringtheminimalresidualdiseaseandbeingmajorityoft

8、hecurrentlyu