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1、Long-TermOutcomesafterTAVI.TechnicalandProceduralRefinementstoReduceLong-termComplicationsParavalvularRegurgitationIanT.MeredithAMMBBS,BSc(Hons),Ph.D,FRACP,FACC,FCSANZ,FSCAI,FAHA,FAPSICProfessorandDirectorofMonashHEARTMonashHealth&MonashUniversity,Melbo
2、urneAustraliaPCRLondonValvesBerlin-Monday21thSeptember2015DisclosureStatementofFinancialInterestWithinthepast12months,Iormyspouse/partnerhavehadafinancialinterest/arrangementoraffiliationwiththeorganization(s)listedbelow.Affiliation/FinancialRelationshi
3、pCompany•ConsultingFees/Honoraria•BostonScientific,•MedtronicPVLandLong-TermOutcomeafterTAVI•Incidence•Longtermimpact•Technical&ProceduralConsiderations•FutureoptionsPost-implant/30DayPVLMixed(Edwards+CoreValve)RealWorldRegistries40A:Hayashida1,N=260Mod
4、erate+Severe%PVL2B:Buchanan,N=3053535C:Gilard3,N=3195D:AbdelWahab4,N=69030,9E:Lange5,N=42030F:VanBelle6,N=2769G:Moat7,N=870H:Gotzmann8,N=14525I:Tamburino9,N=218J:Al-Lamee10,N=1627K:Eltchaninoff11,N=2442017,717,5L:Wenawaser12,N=68215,5M:Hamm13,N=269414,8
5、1513,613N:Puls14,N=180Patients*(%)12,6O:Stahli15,N=130109,5P:Fraccaro16,N=384108,8Q:Stohr17,N=1757,374,54530ABCDEFGHIJKLMNOPQ*PVLratesfromevaluabledata1Hayashida,etal.JofAmCollofCardiol2012;59(6).,2Buchanan,etal.EuroIntervention2011;7:556-563.,3Gilard,e
6、tal.NEnglJMed2012;366:1705-15.,4Abdel-Wahab,etal.Heart2011;97:899-906.,5Lange,etal.JACCJan2012:280-7.,6VanBelle,etal.Circulation2014;129:1415-1427.,7Moat,etal.JofAmCollofCardiol2011;58(20).,8Gotzmann,etal.AmHeartJ2011;162:238-245.,9Tamburino,etal.AmJofC
7、ardiol2012May15;109(10):1487-1493.,10Al-Lamee,etal.AJC2013.,11Eltchaninoff,etal.EurHeartJ2011;32:191-197.,12Wenaweser,etal.EuroIntervention2014;9-onlinepublished-ahead-of-printApril2014.,13Hamm,etal.doi:10.1093/eurheartj/eht381.,14Puls,etal.ClinResCardi
8、ol2012;101:553-563.,15Stahli,etal.JInvasiveCardiol2011;23:307-312.,16Fraccaro,etal.Circulation2012;5:253-260.,17Stohr,etal.CoronaryArteryDisease2011;22:595-600.Post-implant/30DayPVLSelectedStudieswithCoreValve25Moderate+Severe%…2
