White Matter Hyperintensities-AD

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1、JournalofGeriatricPsychiatryandNeurologyVolume22Number3WhiteMatterHyperintensitiesandSeptember2009207-212#2009TheAuthor(s)10.1177/0891988709335800CognitiveDysfunctioninAlzheimerhttp://jgpn.sagepub.comDiseaseJae-HyeokHeo,MD,Soon-TaeLee,MD,KonChu,MD,Hyun

2、-JungPark,BS,Ji-YoungShim,BS,andManhoKim,MD,PhDTheeffectofwhitematterlesionsinmagneticreso-(grade0).Fourteenpercentage(20/142)weregradenanceimagingorvascularatherosclerosisoncognitive1,42%(59/142)grade2,and14%(20/142)weregradefunctionisnotfullyundersto

3、odinAlzheimerdisease3.MeanK-MMSEscoresdeclinedasMRIgrades(AD).Inthisinvestigation,weexaminedtheinfluenceincreasedtograde2and3comparedtograde0(P

4、withAD(44men,meanagebyMRIgrade.Theseresultsremainedsignificantafter65.7+7.6years;meaneducationperiod7.8+5.0adjustingforcompoundingfactorsaffectingcognitiveyears)wereincluded.Patientsweredividedinto4functions;sex,age,numberofyearsinfull-timeeduca-groups

5、basedontheseveritiesofwhitematterhyperin-tion,hypertension,diabetes,hypercholesterolemia,tensities(WMH)inbrainmagneticresonanceimagessmoking,andatrialfibrillation.ThepresenceofWMHs(MRI)usingFazekasscale.CognitivefunctionswerewereassociatedwithscoreofMM

6、SEandCDRimpair-determinedusingtheKoreanversionoftheMini-mentinpatientswithAD.ThesefeaturescouldbeaMentalStateExamination(K-MMSE)andtheClinicalcorrectablefactorhasteningcognitivedeclineinAD.DementiaRating(CDR)scalebeforeacetylcholinester-aseinhibitorswe

7、readministered.Ofthe142patients,Keywords:Alzheimerdisease;whitematterhyperin-30%(43/142)hadnowhitemattersignalabnormalitytensities;cognitiveimpairmentIntroductionthatis,apolipoproteinE(APOE)genotype,plasma2homocysteinlevels,andinflammatorycytokines.Alz

8、heimerdisease(AD)isthemostcommoncauseofMoreover,atherosclerosishasbeensuggestedtoseniledementiaanditsprevalencesteadilyincreaseshavearoleinthepathogenesisofAD,becauseofitswithage.Similarly,whitematterhyperintensitiesstrongassociationwit