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1、NIHPublicAccessAuthorManuscriptIntJNeurosci.Authormanuscript;availableinPMC2011June6.NIH-PAAuthorManuscriptPublishedinfinaleditedformas:NIH-PAAuthorManuscriptNIH-PAAuthorManuscriptIntJNeurosci.2010August;120(8):544±550.doi:10.3109/00207454.2010.494788.DiagnosticUtilityofCer
2、ebralWhiteMatterIntegrityinEarlyAlzheimer'sDiseaseDavidK.Johnson1,WillisBarrow2,RaeAnnAnderson1,AmithHarsha2,RobynHonea2,WilliamM.Brooks3,andJeffreyM.Burns21DepartmentofPsychology,UniversityofKansas,Lawrence,Kansas,USA2DepartmentofNeurology,UniversityofKansas,SchoolofMedici
3、ne,KansasCity,Kansas,USA3HoglundBrainImagingCenter,UniversityofKansasMedicalCenter,KansasCity,Kansas,USAAbstractWecomparedwhitematterintegritywithbrainatrophyinhealthycontrolsandparticipantswithverymilddementia(ClinicalDementiaRating0vs.0.5)fromtheBrainAgingProject,alongitu
4、dinalstudyofagingandmemoryattheUniversityofKansasMedicalCenter.Structuralmagneticresonanceimaginganddiffusiontensorimaging(DTI)includingfractionalanisotropyandmeandiffusivitywereperformedon27patientswithverymilddementia(ClinicalDementiaRating=0.5)oftheAlzheimer'stype(DAT),a
5、nd32cognitivelynormalsubjects.Patientgroupswerecomparedacross6volumetricmeasuresand14DTIregionsofinterest.Verymildlydementedpatientsshowedexpecteddisease-relatedpatternsofbrainatrophywithreductionsinwhole-brainandhippocampalvolumesmostprominent.DTIindicesofwhitematterintegr
6、ityweremixed.Rightparahippocampusshowedsignificantbutsmalldisease-relatedreductionsinfractionalanisotropy.RightparahippocampusandleftinternalcapsuleshowedgreatermeandiffusivityinearlyDATcomparedwithcontrols.Aseriesofdiscriminantanalysesdemonstratedthatgraymatteratrophywasas
7、ignificantlybetterpredictorofdementiastatusthanwereDTIindices.BrainatrophywasmoststronglyrelatedtoverymildDAT.Modestdisease-relatedwhitematteranomalieswerepresentintemporalcortex,anddeepwhitematterhadlimiteddiscriminatorydiagnosticpower,probablybecauseoftheverymildstageofdi
8、seaseintheseparticipants.KeywordsAlzheimer'sdisease;brainatrophy;diffusiontensorim
