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3、lledfood792.challenge:aclinicalstudyin32subjectswithahistoryof[收稿日期:2003-03-28]中图分类号:R15;Q3431文献标识码:E文章编号:1004-8456(2003)03-0238-07有机锡化合物的污染及其毒性王永芳(卫生部卫生监督中心,北京100007)摘要:为了解有机锡化合物污染及其毒性的研究成果,从有机锡化合物对海洋的污染状况、污染来源、有机锡化物对海洋生物以及人体健康的毒性等方面进行了综述。实验证明有机锡化合物尤其是三苯基锡和三丁基锡,能够引起雌性软体动物变性、哺乳细胞生殖毒性、以及人体免疫毒性
4、等。有机锡化合物作为一种防污涂料被广泛应用于船体和海洋建筑等,因此导致了海产品中残留了大量的有机锡化合物,这些化合物可以通过食物链影响人体健康。人类食用了含有机锡化合物的海产品后,对人体健康可能造成的潜在危险,其危害机理尚需进一步研究。关键词:有机锡化合物;环境污染;食品污染ThecontaminativestatusoforganictincompoundsanditstoxicityWangYongfang(NationalCenterforHealthInspectionandSupervision,China,Beijing100007)Abstract:Thecontaminati
5、vestatusandthesourcesoforganictin(organotin)compoundsinmarineenvironmentanditstoxicitytomarineanimalandhumanweresummarized.Ithasbeenfoundthatorganotincompoundcaninduceimposexinfemalegastropods,reproductivetoxicityandgenotoxicityonmammaliancells,andimmunotoxicityonhumancellsinvitro,especiallytriphe
6、nyltincompounds(TPT)andtributyltincompounds(TBT).Organotincompoundswerewidelyusedasantifoulingpaintsforboatsandothermarinebuildings,andorganotincompoundswereaccumulatedinseaproducts.Theorganotincompoundswereaccumulatedinthefoodchainandinducinghazardouseffectonhumanhealth.Theoccurrenceoforganotincomp
7、oundsinseaproductsindicatedapotentialdangerforthehealthofpeopleconsumingseafood.Moreinformationisneededtodeterminetheriskoforganotincompoundstohumanhealth.KeyWords:OrganotinCompound;EnvironmentContam
