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1、Medicine®OBSERVATIONALSTUDYPrognosticSignificanceofSingleProgesteroneReceptorPositivityAComparisonStudyofEstrogenReceptorNegative/ProgesteroneReceptorPositive/Her2NegativePrimaryBreastCancerWithTripleNegativeBreastCancerYingFan,MD,XiaoyanDing,MD,BingheXu,MD,PhD,FeiMa,MD
2、,PengYuan,MD,JiayuWang,MD,PinZhang,BcS,QingLi,BcS,andYangLuo,MDAbstract:Singleprogesteronereceptorpositive(PgRþ),especiallyinTNBC,suggestingthatitshouldalsoberegardedasbiologicallyformofER/PgRþ/HER2,isanonnegligiblephenomenon.LittleisdistinctivegroupandsinglePgRpositi
3、veitselfisnotagoodprognosticknownaboutthecharacteristicsandtheroleofsinglePgRpositiveinfactor.However,adjuvantendocrinetherapycouldstillbenefitthisthisphenotype.Therefore,weexplorethesignificanceofsinglePgRgroupofpatients.Furtherinvestigationsshouldbedonetoelucidatethepos
4、itivitybycomparingER/PgRþ/HER2breastcancerswithtripleunderlyingmechanism.negativebreastcancers(TNBCs).(Medicine94(46):e2066)Threethousandninehundredsixty-sixcasesofprimaryinvasivebreastcarcinomaoperatedconsecutivelyfromJanuary2005toMayAbbreviations:AJCC/UICC=AmericanJ
5、ointCommitteeon2008inCancerHospital,ChineseAcademyofMedicalScienceswereCancer/InternationalUnionAgainstCancer,ASCO/CAP=examined.Twohundredforty(6%)caseswereidentifiedasER/AmericanSocietyofClinicalOncology/CollegeofAmericanPgRþ/HER2breastcancersand348(8.8%)casesasTNBCs.
6、Clin-Pathologists,BCS=breastconservingsurgery,BMI=bonemassicopathologicalcharacteristicsandsurvivalswereanalyzedrespectivelyindex,ER=estrogenreceptor,HER2=humanepidermalgrowthandthencomparedbetween2subtypes.factorreceptor2,IDC=invasiveductalcarcinoma,MRM=Comparedwithpat
7、ientswithTNBCs,ER/PgRþ/HER2tumormodifiedradicalmastectomy,NA=notapplicable,OS=overalltendedtohavelowertumorgrade(Grade3:45.7%vs.37.5%,survival,PgR=progesteronereceptor,RFS=relapse-freesurvival,P¼0.051)andsmallertumorsize(P¼0.036).However,nodifferencesSD=standarddeviati
8、on,TNBCs=triplenegativebreastcancers.werefoundbetweenER/PgRþ/HER2andTNBCpatientsinrelapse-freesurvival(RFS)a
