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1、Stress,depression,and4mania:relationship0I0I.betweenperceivedroleofstressfuleventiandclinikalandbiochemicalcharacteristicsSwamAC,SecundaSK,StokesPE,CroughanJ,DavisJM,KoslowA.C.Swann',S.K.Secunda2,P.E.SH,MaasJW.Stress,depression,andmania:relationshipbetweenper-Stokes3,J.Croughan4,J.M.Da
2、vis6,ceivedroleofstressfuleventsandclinicalandbiochemicalcharacteristics.S.H.KOSIOW~,J.W.Maas7ActaPsychiatrScand1990:81:389-397.'DepartmentofPsychiatry,UniversityofTexasMedicalSchool,Houston,Texas,*Springfield,WeinvestigatedtheperceivedroleofstressfuleventsinepisodesofmajorPe'nnsylvani
3、a,DepartmentofPsychiatry,affectivedisorderinpatientsstudiedintheNIMHClinicalResearchPayneWhitneyPsychiatricClinic,CornellUni-BranchCollaborativeProgramonthePsychobiologyofDepressionversityMedicalCenter,NewYork,NewYork,(BiologicalStudies).UsingitemsfromtheScheduleforAffectiveDisordersDe
4、partmentofPsychiatry,WashingtonUni-andSchizophrenia(SADS),episodesweredividedintoenvironment-versitySchoolofMedicine,St.Louis,Missouri,sensitive(highperceivedroleofstressfulevents)andautonomous(minimalIllinoisStatePsychiatricCenter,Chicago,ornoperceivedroleofstressfulevents).Patientswi
5、thenvironment-sensitiveIllinois,'DivisionofBasicSciences,NationalInstituteofMentalHealth,Rockville,Maryland,episodeshadfewerpreviousepisodesandalongerindexepisode.The'DepartmentofPsychiatry,Universityofgroupsdidnotdifferwithrespecttoage,gender,education,socioeconomicTexasHealthScienceC
6、enter,SanAntonio,group,diagnosis,severityofillness,oreventualresponsetotreatment.Texas,USAUnipolardepressedpatientswithenvironment-sensitiveepisodeshadlowerCSF5-HIAAthanthosewithautonomousepisodes.Amongbipolardepressedpatients,thosewithautonomousepisodeshadelevatedexcretionof0-methylat
7、edcatecholaminemetabolitesandofepinephrine,whilethosewithenvironment-sensitiveepisodeshadnormalexcretionofcate-Keywords:affectivedisorder;depression;cholaminesandmetabolites.Manicsubjectswithenvironment-sensitivemania:lifeevent;catecholamine;norepinephrineepisodeshadelevatednorepinep
