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《Sequence-based identification of 3D structural modules in RNA with RMDetect》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。
1、Articlessequence-basedidentificationof3dstructuralmodulesinrnAwithrmdetectJoséAlmeidaCruz&EricWesthofstructuralrnAmodules,setsoforderednon-Watson-crickarraysoforderednon-Watson-Crickbasepairs3.ThisdistinctionbasepairsembeddedbetweenWatson-crickpairs,havecent
2、ralseparates‘objects’thatexistintertiarystructurefromthosethatrolesasarchitecturalorganizersandsitesofligandbindinginexistonlyinsequence.rnAmolecules,andarerecurrentlyobservedinrnAfamiliesTheidentificationofamoduleinaRNAsequencecanprovidethroughoutthephyloge
3、ny.herewedescribeacomputationalkeyinformationaboutthesecondarystructureandtheresultingtool,rnAthree-dimensional(3d)modulesdetection,ortertiaryfold7–9.Therefore,theidentificationofastructuralRNArmdetect,foridentifyingknown3dstructuralmodulesinmodulelendssuppo
4、rttotheidentificationofatranscriptasasingleandmultiplernAsequencesintheabsenceofanyotherstructuredRNA10,presentscluesforthelocalfunctionoftheinformation.currently,fourmodulescanbesearchedfor:molecule11,12andexplainschemicalprobingdatabecausemod-G-bulgeloop,k
5、ink-turn,c-loopandtandem-GAloop.incontrolulespresentdefinedchemicalprobingsignaturesandmutationaltestsequenceswefoundalloftheknownmoduleswithadata4.Recenttoolsformodulesearchinginstructures13–16illus-falsediscoveryrateof0.23.scanningthrough1,444publiclytrate
6、theimportanceofmodulediscovery.However,noneoftheseavailablealignments,weidentified21yetunreportedmodulestoolshavebeendesignedtofindmodulesinsequencealone.and141knownmodules.rmdetectcanbeusedtorefineSeveralRNAmotifsearchtoolsarecurrentlyavailable.SomernA2dstr
7、ucture,assemblernA3dmodels,andsearchand(RNAMotif5orMilPat17)relyonuser-defineddescriptorsofannotatestructuredrnAsingenomicdata.sequenceandsecondarystructure.Others(CMFinder6)inferassembliesofsecondary-structureelementsfromhomologousStructuredRNAspresenthiera
8、rchicalarchitecturesinwhichsequences.Thesetoolssearchforspecificsecondarystructuredouble-strandedhelicesandsingle-strandedloopsareorgan-elementsthatcanspanuptohundredsofnucleotideswithexten-ized
