Fano-resonant asymmetric metamaterialsfor ultrasensitive spectroscopy and identification of molecular monolayers

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1、ARTICLESPUBLISHEDONLINE:13NOVEMBER2011

2、DOI:10.1038/NMAT3161Fano-resonantasymmetricmetamaterialsforultrasensitivespectroscopyandidentificationofmolecularmonolayersChihhuiWu1,AlexanderB.Khanikaev1,RonenAdato2,NihalArju1,AhmetAliYanik2,HaticeAltug2*andGennadyShvets1*Engineeredopticalmetamaterials

3、presentauniqueplatformforbiosensingapplicationsowingtotheirabilitytoconfinelighttonanoscaleregionsandtotheirspectralselectivity.Infraredplasmonicmetamaterialsareespeciallyattractivebecausetheirresonantresponsecanbeaccuratelytunedtothatofthevibrationalmodesofthetargetbiomolecules.Hereweintroduc

4、eaninfraredplasmonicsurfacebasedonaFano-resonantasymmetricmetamaterialexhibitingsharpresonancescausedbytheinterferencebetweensubradiantandsuperradiantplasmonicresonances.Owingtothemetamaterial’sasymmetry,thefrequencyofthesubradiantresonancecanbepreciselydeterminedandmatchedtothemolecule’svibr

5、ationalfingerprints.AmultipixelarrayofFano-resonantasymmetricmetamaterialsisusedasaplatformformultispectralbiosensingofnanometre-scalemonolayersofrecognitionproteinsandtheirsurfaceorientation,aswellasfordetectingchemicalbindingoftargetantibodiestorecognitionproteins.n-depthunderstandingoflife-

6、sustainingbiomolecularbindingsurface-enhancedspectroscopies9,11,12.Especiallyimportantforprocesseshasthepotentialforimpactingeverycorneroflifebiosensingapplicationsareinfraredmetamaterials,becauseIsciencesandmedicine1,2.Ingeneral,conformationalrearrange-biomoleculespossessmid-infraredvibratio

7、nalfingerprintsthatmentsinbiomolecularstructuresarerequiredformatchingthecanbeusedfortheiridentification,therebyimprovingthebindingsitesbetweenthehostandguestmolecules3,4.However,specificityofbiodetection26.state-of-artbiosensingtechniquescanonlyprobethebiomaterialWhereastheconceptoftuningmet

8、amaterialresonancestoaccumulationsduetomolecularbindings57,nottheunderly-specificvibrationallinesofabiomoleculeisstraightforward13,itsingconformationalalterationsrequiredforbindingprocessestoactualimplementationiscomplicatedbydensespectralsp