并殖吸虫病Paragonimia

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1、ParagonimiasisIntruductionAkindofchronicdiseasecausedbyparagonimuswestermani,paragonimusszechuanensisandseveralotherrelatedspeciesAdultwormofparagonimuswestermaniinhabitlungsofthefinalhost,causingcough,chestpain,rustysputumandhemoptysisparagonimusszechuanensiscausesubcut

2、aneousnodulesandmassesInfectedbyeatingrawcrayfishandfreshwatercrabEtiologyMorphologyAdultworm:theyaremonoecious,thereproductiveorgansareparallel,havetwosuckersEggs:goldenbrown,ovate,operculate,thesizeis80-120×48-60mMetacercariae:roundorovate.Diameter300-400m,1-3layerso

3、fcystwallLifeCycleManwithadultwormtomaturepassingeggsintowater2-3months21dayseatingmiracidiMetacercariafirstintermediatehost(specialsnail)secondintermediatehost3months(crayfishandfreshwatercrab)cercariaEpidemiologySourceofinfection:humansmammalsandotherwormcarriers,which

4、canproduceeggsRouteoftransmission:1.Thepresenceofthefinalhost:patientsandtheinfectedmammals2.Thepresenceofalargeamountof1stand2ndintermediatehost3.ThehabitofeatingthefreshwatercrayfishandcrabSusceptibility:everyoneissusceptiveCharacterofEpidemicWidelydistributed:Asia,Afr

5、ica,Americainourcountry,morethan21provincesareinvolvedintheinfectionItmainlyoccursinsummerandautumnNorth:thetypeofcrayfishepidemicSouth:thetypeoffreshwatercrabepidemicPathogenesisandPathogenProcessCausedbyJuvenileWormsMetacercariaeexcystinduodenum,andintoabdominalcavity,

6、themigratecausemechanicallesionsPenetratediaphragmsintopleuralcavitytocauselungcystThepathologicalchangecausedbypagumogonimusskjabininclude:subcutaneousnodulesmass,exudativepleurisy,liverlesion,andeosinophilia.ThetypicallesionareeosinophilousgranulomasProcessCausedbyAdul

7、tWormsInhabitlungsMigratethroughlaceratedforamenintocranialcavity,invadeintothebrainInvadeintogreaterpsoasmuscleMigratethroughintervertabralforamenintoepiduralcavityAllthesecausingspaceoccupyinglesionProcessCausedbyEggsThereactionisslightBasicPathologicalLesionTheprocess

8、aredividedintothreestages:Abscessstage:thewormsmigratefromintestinetolung,resultinhemorrhagenecrosisoft