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1、ParagonimiasisIntruductionAkindofchronicdiseasecausedbyparagonimuswestermani,paragonimusszechuanensisandseveralotherrelatedspeciesAdultwormofparagonimuswestermaniinhabitlungsofthefinalhost,causingcough,chestpain,rustysputumandhemoptysisparagonimusszechuanensiscausesubcutaneo
2、usnodulesandmassesInfectedbyeatingrawcrayfishandfreshwatercrabEtiologyMorphologyAdultworm:theyaremonoecious,thereproductiveorgansareparallel,havetwosuckersEggs:goldenbrown,ovate,operculate,thesizeis80-120×48-60mMetacercariae:roundorovate.Diameter300-400m,1-3layersofcystwal
3、lLifeCycleManwithadultwormtomaturepassingeggsintowater2-3months21dayseatingmiracidiMetacercariafirstintermediatehost(specialsnail)secondintermediatehost3months(crayfishandfreshwatercrab)cercariaEpidemiologySourceofinfection:humansmammalsandotherwormcarriers,whichcanproduceeg
4、gsRouteoftransmission:1.Thepresenceofthefinalhost:patientsandtheinfectedmammals2.Thepresenceofalargeamountof1stand2ndintermediatehost3.ThehabitofeatingthefreshwatercrayfishandcrabSusceptibility:everyoneissusceptiveCharacterofEpidemicWidelydistributed:Asia,Africa,Americainour
5、country,morethan21provincesareinvolvedintheinfectionItmainlyoccursinsummerandautumnNorth:thetypeofcrayfishepidemicSouth:thetypeoffreshwatercrabepidemicPathogenesisandPathogenProcessCausedbyJuvenileWormsMetacercariaeexcystinduodenum,andintoabdominalcavity,themigratecausemecha
6、nicallesionsPenetratediaphragmsintopleuralcavitytocauselungcystThepathologicalchangecausedbypagumogonimusskjabininclude:subcutaneousnodulesmass,exudativepleurisy,liverlesion,andeosinophilia.ThetypicallesionareeosinophilousgranulomasProcessCausedbyAdultWormsInhabitlungsMigrat
7、ethroughlaceratedforamenintocranialcavity,invadeintothebrainInvadeintogreaterpsoasmuscleMigratethroughintervertabralforamenintoepiduralcavityAllthesecausingspaceoccupyinglesionProcessCausedbyEggsThereactionisslightBasicPathologicalLesionTheprocessaredividedintothreestages:Ab
8、scessstage:thewormsmigratefromintestinetolung,resultinhemorrhagenecrosisoft