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1、AmJPhysiolCellPhysiol280:C763±C768,2001.Differentialglobalgeneexpressioninredandwhiteskeletalmuscle1,21,21,2W.G.CAMPBELL,S.E.GORDON,C.J.CARLSON,21,21,2J.S.PATTISON,M.T.HAMILTON,ANDF.W.BOOTH1DepartmentofIntegrativeBiology,UniversityofTexasMedicalSchool,Houston,Texas77030;and
2、2DepartmentsofVeterinaryBiomedicalSciencesandPhysiologyandDaltonCardiovascularCenter,CollegeofVeterinaryMedicine,UniversityofMissouri,Columbia,Missouri65211Received1March2000;acceptedin®nalform26October2000Campbell,W.G.,S.E.Gordon,C.J.Carlson,J.S.Themetabolicpro®leofredvs.w
3、hitemusclemaybePattison,M.T.Hamilton,andF.W.Booth.Differentialprotectiveagainstthedevelopmentandprogressionofglobalgeneexpressioninredandwhiteskeletalmuscle.Amchronicdisease.IndividualswithahigherpercentageJPhysiolCellPhysiol280:C763±C768,2001.ÐThediffer-ofred®bersarelessli
4、kelytohavechronicmetabolicencesingeneexpressionamongthe®bertypesofskeletalsyndromes,suchasinsulinresistance(11,14,18,19,musclehavelongfascinatedscientists,butforthemostpart,31),glucoseintolerance(31),type2diabetes(25),obe-previousexperimentshaveonlyreporteddifferencesofoneo
5、rsity(10,11,17±19,28,33),andabloodlipidpro®letwogenesatatime.TheevolvingtechnologyofglobalmRNAassociatedwithanincreasedriskofcardiovascularexpressionanalysiswasemployedtodeterminethepotentialdisease(lowhigh-densitylipoprotein,lowapolipopro-differentialexpressionof;3,000mRNA
6、sbetweenthewhiteteinA-I,andhightriglycerides)(30).Thustheabilityofquad(whitemuscle)andtheredsoleusmuscle(mixedredskeletalmuscletooxidizesubstrateslikelyplayssomemuscle)offemaleICRmice(30±35g).Microarrayanalysisidenti®ed49mRNAsequencesthatweredifferentiallyex-roleinchronicme
7、tabolicdiseases.pressedbetweenwhiteandmixedredskeletalmuscle,in-Theabilitytostudygeneexpressiondifferenceswithcludingnewlyidenti®eddifferentialexpressionsbetweenoligonucleotidearraysmayenableresearcherstode-muscletypes.Forexample,thecurrent®ndingsincreasetheterminethosegene
8、sresponsibleforthediversityofnumberofknown,differentiallyexpressedmRNAsfortran-mus
