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1、CurrentTopicsinMedicinalChemistry2004,4,241-265241RecentStudiesonNaturalProductsasAnticancerAgentsÁngelG.Ravelo*,AnaEstévez-Braun,HaydeeChávez-Orellana,ElisaPérez-Sacau,DulceMesa-SiverioInstitutoUniversitariodeBio-Orgánica“AntonioGonzález”,UniversidaddeLaLaguna,Avda.Astro
2、físicoFco.Sánchez2.38206.LaLaguna,Tenerife,SpainstAbstract:Cancerwillbethemajorcauseofdeathinthe21centuryandnaturalproductsshouldprovidenovelandmoreeffectiveanticanceragents.Thisreviewdealswithnewnaturalmoleculesliabletobecomeanticancerdrugs,aswellasrecentspecificstrategi
3、esforaselectivetreatmentofcancer.Theintroductionpresentsthecurrentstateoftheartonanticancerresearch.Beside,inthefollowingsubheadingswesummarizeourresearchoncytotoxicnaturalquinonemethide-triperpenesandtheiranalogues.Wealsodiscussourresultsontheanti-tumourpromotingactivity
4、ofnaturalnaphthoquinonesandtheirderivatives.1.INTRODUCTIONmoleculelibrariescanbeusedtoidentifyandstudypreviouslyunknowntargets[17-18].Thetraditionalmedicinesystems,basedonplants,havebeenusedallovertheworldforthousandsofyears[1-4].Despitetheever-increasingdemandofnewnatura
5、lTheseplantbasedsystemscontinuetoplayanessentialroleproducts,theirisolationandstructureelucidationstillremaininhealthcare.TheWHO(WorldHealthOrganization)alabor-intensiveprocess[8,19-20].Asanalternative,estimatesthatapproximately80%oftheworld’sinhabitantschemistsarenowenli
6、stingthetoolsofsolid-phasecombi-relymainlyontraditionalmedicinefortheirprimaryhealthnatorialsynthesistoconstructlibrariesofnaturalproductcare[5-6].Toalargeextent,theuseofnaturalproductsinanaloguesandnaturalproductlikecompounds[21-23].Theredrugdesignrepresentsthenaturalevo
7、lutionofthisoldareexamplesofthisapproachbaseduponthenaturaltradition.Naturalproductshavehadamajorimpactasproductspaclitaxel[24]andepothilones[25-26].Nicolaoutemplatesordirecttreatmentsforcancersandinfective[27-29]introducedthisstrategyfortheconstructionofdiseases.Inthecan
8、cerarea,ofthe92drugscommerciallynaturalproduct–likelibrariesusingtheconceptofprivilegedavailable
