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1、CurrentTopicsinMicrobiologyandImmunologyVolume320SeriesEditorsRichardW.CompansEmoryUniversitySchoolofMedicine,DepartmentofMicrobiologyandImmunology,3001RollinsResearchCenter,Atlanta,GA30322,USAMaxD.CooperHowardHughesMedicalInstitute,378WallaceTumorInstitute,1824SixthAvenueSou
2、th,Birmingham,AL35294-3300,USATasukuHonjoDepartmentofMedicalChemistry,KyotoUniversity,FacultyofMedicine,Yoshida,Sakyo-ku,Kyoto606-8501,JapanHilaryKoprowskiThomasJeffersonUniversity,DepartmentofCancerBiology,BiotechnologyFoundationLaboratories,1020LocustStreet,SuiteM85JAH,Phil
3、adelphia,PA19107-6799,USAFritzMelchersBiozentrum,DepartmentofCellBiology,UniversityofBasel,Klingelbergstr.50–70,4056BaselSwitzerlandMichaelB.A.OldstoneDepartmentofNeuropharmacology,DivisionofVirology,TheScrippsResearchInstitute,10550N.TorreyPines,LaJolla,CA92037,USASjurOlsnes
4、DepartmentofBiochemistry,InstituteforCancerResearch,TheNorwegianRadiumHospital,Montebello0310Oslo,NorwayPeterK.VogtTheScrippsResearchInstitute,Dept.ofMolecular&Exp.Medicine,DivisionofOncovirology,10550N.TorreyPines.BCC-239,LaJolla,CA92037,USAPatrickJ.Paddison•PeterK.VogtEdito
5、rsRNAInterferencePatrickJ.PaddisonPeterK.VogtColdSpringHarborFellowsProgramTheScrippsResearchInstituteColdSpringHarborLaboratoryDepartmentofMolecular&ExperimentalColdSpringHarbor,NY11771Medicinee-mail:paddison@cshl.eduDivisionofOncovirology10550N.TorreyPinesRoad,BCC-239LaJoll
6、a,CA92037USAe-mail:pkvogt@scripps.eduCoverIllustration:AmodelofthesmallRNAtranscriptionalsilencingcomplexisshownwiththetranscriptionbubbleandRNAPII(darkblue),Argonaute1(green),andtheantisensestrandofthesmallRNA(red)boundtonascentmRNA(alsored).Anepigeneticregulatorycomplexcomp
7、osedofEzh2,DNMT3a,andHDAC-1isalsoshown(red,blueandgreen),remodelingthehistone.(ComputergraphicscourtesytoPaulaJ.Morris).ISBN978-3-540-75156-4e-ISBN978-3-540-75157-1CurrentTopicsinMicrobiologyandImmunologyISSN007-0217xLibraryofCongressCatalogNumber:72-152360©2008Springer-Verla
8、gBerlinHeidelbergThisworkissubjecttocopyright.Allrightsreserved,whet
