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1、#374#喻杰,等rhTPO和IL-11治疗NSCLC化疗后血小板减少症的临床观察×临床应用研究ØrhTPO和IL-11治疗NSCLC化疗后血小板减少症的临床观察1222喻杰,戴晓芳,刘莉,伍钢1.江苏省苏北人民医院放化疗科,江苏扬州2250012.华中科技大学附属协和医院肿瘤诊疗中心,湖北武汉430022Clinicalstudiesofrecombinanthumanthrombopoietinintreatmentofgemzarandcisplatin-inducedthrombocytopeniainpatients
2、withnon-smallcelllungcancerYUJie1,DAIXiao-fang2,LIU-Li2,WUGang21.DepartmentofRadiotherapyandChemotherapy,SubeiPeople.sHospitalofJiangsuProvince,Yangzhou225001,P.R.China2.CancerCenter,UnionHospital,Hua-zhongUniversityofScienceandTechnology,Wuhan430022,P.R.China=摘要>目的
3、:对比研究重组人血小板生成素[ABSTRACT]OBJECTIVE:Toevaluatetheefficacyand(rhTPO)及IL-11治疗非小细胞肺癌(NSCLC)safetyofrecombinanthumanthrombopoietin(rhTPO)inthe化疗后血小板减少的疗效及安全性。方法:采treatmentofgmzarandcisplatin-inducedthrombocytopeniain用前瞻性、平行对照研究方法对62例经病理学patientswithnon-smallcelllungcancer
4、.METHODS:Sixty-或细胞学确诊的NSCLC,采用健择、顺铂联合twopatientswereenrolledwhentheirplateletcountwaslower化疗方案后血小板[75@109L-1患者进行分than75@109L-1afterchemotherapy.Twenty-eightpatientsin组。治疗组:皮下注射特比澳15000U/d;对照thetreatmentgroupreceivedadoseof15000U/drhTPO,34组:皮下注射吉巨芬3mg/d。结果:治疗组与对patie
5、ntswhoreceivedadoseof3mg/drhIL-11wererandomly照组比较,化疗后第21天血小板值分别为chosedastheparalleledcontrols.RESULTS:Inthetreatment16413@109L-1和112156@109L-1,P=group,theplateletcountatthetwenty-firstdayafterchemothera-01011;血小板最低值分别为4410@109L-1和py,themeanminimalplateletcount,andth
6、emeanmaximalplate-9-1letcountwere164.3@109L-1,44.0@109L-1,and277.1@3317@10L,P=01026;血小板恢复最高值分别为27711@109L-1和13511@109L-1(P=109L-1respectively,allsignificantlyhigherthanthoseofthecon-01000),治疗组明显高于对照组。治疗组15例trolgroup(112.56@109L-1,33.7@109L-1,and135.1@9-1发生Ó度血小板下降,持续
7、平均天数为2160d;10Lrespectively,(P=0.011,0.026,0.000).Fifteenpa-对照组为29例及4100d,差异有统计学意义tientsinthetreatmeatgroupand29patientsinthecontrolgroup(P=01006,P=0102);治疗组4例发生Ô度血weredemonstratedÓthrombocytopenia(P=0.006),thedeuration小板下降,持续平均天数为110d;对照组为14were2.60dand4.00drespecti
8、vely(P=0.02)and4inthetreat-例及1186d,差异有统计学意义(P=01036,men-tgroupand14patientsinthecontrolgroupweredemonstratedP=01012)。治疗组化疗后血小板恢复至Ôthromboc
