胸骨上小切口大鼠左心室肥厚与其逆转模型的建立和分析

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1、第三军医大学硕士学位论文英文缩写一览表英文缩写英文全称中文全称ABaorticbanding升主动脉缩窄AB3w3weeksafteraorticbanding升主动脉缩窄后3周AB9w9weeksafteraorticbanding升主动脉缩窄后9周AB15w15weeksafteraorticbanding升主动脉缩窄后15周ColⅠcollagenIⅠ型胶原纤维ColⅢcollagenⅢⅢ型胶原纤维DB6w6weeksafteraorticdebanding升主动脉去缩窄后6周EFejectionfraction射血分数ExLVDdexternalleftventricu

2、lardiastolicdiameter左室舒张末外径HEHaematoxylinEosinstainingHE染色HRheartrate心率IVSinterventricularseptumatdiastole舒张期室间隔厚度LVEDleftventricularend-diastolicdiameter左室舒张末内径LVEDPleftventricularend-diastolicpressure左室舒张末压LVESleftventricularend-systolicdiameter左室收缩末内径LVMIleftventricularmassindex左心室质量指数LVP

3、Wleftventricularwallposteriorthicknessat舒张期左室后壁的厚度diastoleLVSPleftventricularsystolicpressure左室收缩压+dp/dtmaxmaximalrateofpressuredevelopment等容收缩期左心室压力上升的最大速率-dp/dtmaxmaximalrateofpressuredecline等容舒张期左心室压力下降的最大速率1万方数据第三军医大学硕士学位论文Establishmentandstudyofratleftventricularhypertrophyregressionmod

4、elthroughsmallincisiononthesuprasternalfossaAbstractBackgroundandobjectivesMyocardialhypertrophyinducedbypressureoverloadisoneoftheimportantcausesofheartfailureandsuddencardiacdeath.Astheclinicalcommoncausesofpressureoverload,aorticstenosisandhypertensioncaninducepersistentpathologicalchange

5、sofcardiachypertrophy,whichmaynotbeeffectivelyreversedbydruginterventiononhypertensionandaorticvalvereplacement,andeventuallyresultinheartfailure.Previousstudiesindicateusthatitisnotenoughtofocusonrelievingthepressureload,soaseriesofinnovativeresearchesdirectingagainstmolecularpathogenesisar

6、ecarriedoutinfullswing.Butfewstudiesareconductedtoexplorechangesofleftventricularhypertrophyandleftventricularfunctioneffectswhenremovingthepressureloadcompletely.Therefore,itisessentialtoestablishanidealmodelaboutleftventricularhypertrophyanditsreversedcondition,whichwellmimicsthetypicalcha

7、ngesduringtheleftventricularpressureoverload-unloadedprocess,tostudythepossiblemolecularpathogenesis.Previousresearchestendtocompletepressureoverloadinducingleftventricularhypertrophybyligatingabdominalaorta.Alsoitisgenerallysupposedthatthecloserto