薄瓣LASIK术后泪液动力学与角膜上皮下神经密度的分析

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1、温州医学院硕士学位论文后第3个月开始，角膜上皮下神经密度开始恢复，飞秒激光组恢复较机械刀组明显，角膜颞侧和鼻侧上皮下神经密度恢复较中央明显；(3)准分子激光角膜磨镶术后，泪液的恢复与角膜上皮下神经密度相关，且早期恢复取决于角膜颞侧和鼻侧上皮下神经密度恢复，飞秒激光术后泪液与角膜上皮下神经密度的恢复优于机械刀组。关键词：准分子激光角膜磨镶术，干眼，泪液动力学，上皮下神经密度4温州医学院硕士学位论文Thestudyoftheteardynamicsandthedensityofsubbasalnervefibersofthecorneaafterthin·

2、flapLASIK．Purpose：Usingultra—LongScanDepthandmultisliceOpticalCoherenceTomography(UL-OCT)andconfocalmicroscopy,tocomparetheteardynamicseffectaftermechanicalmicrokeratome(MM)andfemtosecond(FS)laserinsitukeratomileusis(LASIK)surgeryforrefractiveerror．Methods：Itisaprospectiveclinic

3、alstudyofcomparison．Weselected120eyesof60patientswitllrefractiveerrorthatmeettheinclusioncriteriorinAffiliatedEyeHospitalofWenzhouMedicalCollegefromJuly，201toJuly，2012，whounderwentoperationofthin-flapLASIK．Accordingtotheflap-cuttingtechnique，theyweredividedinto2groups，mechanical

4、microkeratome(MM)groupandfemtosecondlaser(FS)group．Beforesurgery，1week，1month，and3monthsaftersurgery，theheightandareaoftheupperandlowertearmemsciwerequantifiedusingUL·OCTandOCTAnalyzerinthestudygroup．Thedensityofsubbasalnervefibers(SND)atthecentral．nasalandtemporalofcorneawasqua

5、ntifiedbyconfocalmicroscopyandNeuronJsoftwareatthesametime．DatawereconductedbystatisticalanalysissoftwareSPSS19．0andP<0．05wasconsideredstatisticallysignificant．TheMMgroupandtheFSgroupwerecomparedatdifferenttimeusinganalysisofrepeatedmeasurement．TheeffectofthetearmenisciandtheSND

6、wasassessedusingPearsoncorrelationcoe仟icient．Results：1)Boththeheightandareaoftheuppertearmenisciwerehigherthanthelowertearmenisciintwogroups．Intheheightandareaoftheuppertearmenisci，thestatisticallysignificantdifferenceswerefoundbetween2groups(F=7．926，p=0．007andF=12．156，p=0．001；r

7、espectively)．2)1monthaftersurgery，fortheSNDatthenasalofcornea，theMMgroupwasstatisticallysignificanthigherthantheFSgroup．3monthaftersurgery，fortheSNDatthecentralandtemporalofcornea,theFSgroupwasstatisticallysignificanthigherthantheMMgroup(F=21．466，p

8、ctively)．butatthenasalofcomea,theFSgroupwasstat