SSTR2，3，5在肝细胞癌中的表达与临床意义

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1、中山大学硕士学位论文SSTR2，3，5在肝细胞癌中的表达及临床意义TheexpressionandclinicalvalueofSST】；匕。3，5in1neeXDreSSlonannCllnlCaIVaIUe0tSS’l’量‘Z．3．5lnhepatocellularMajor：oncoIogyCarClnomaGraduatestudent：GuoZhixingSuperVisor：Prof：GuoRongpingABSTRACTBACKGRoUD&oBJECTIVE：Hepatocellularcarcinoma(HCC)isoneofthemost矗equentm

2、a王ignancies．InChina，HCCisthesecondmoStf琵quentcauseofmalignancy-relateddeath．Somatostatin(SST)，oneofpolypeptideho珊ones，wasfirstlyfoundincentralnervouSsyStem．Thebiologicalactivi够ofsomatostatinismediatedthrou曲somatoStatinreceptors(SSTIUontargetcells．SSTcanregulatetheproliferationofno珊alcells

3、andturnorcells．BasedontheeXpressionofSSTRonHCCcell，sometrialsshowthatsurViValbenefitforu眦esectableHCCpatientstreatedwithoctreotide—akindofSSA．TheexpressionofSSTRonHCCaredi彘rentinstudies．TllroughthemethodofimmunohistochemistⅨthisstudywastoinVestigatetheexpressionstatusofSSTR2，3，5inHCCtissu

4、e戳1dthecliIlicalvalueonHCCpatients．METHoDS：Im瑚unohistochemistr)，techniquewaSusedtodetecttheexpressionofSSTR2，3，5in95eaSesofHCCtissues，para·carcinomatissueand1OcasesofnomalliVertissues．nledi艉renceoftheexpressionofSSTR2，3，5in缸eetissuesandthecorrelationoftlleexpressionofth￡threeproteinswerea

5、nalyzed．Also，therelationshipofmethreeproteinswithclinicpathologicdataandprognosisofHCCpatientswereanalyzed．nI中山大学硕士学位论文SSTR2，3，5在肝细胞癌中的表达及临床意义RESUl月S：InHCCtissue，nlem曲expressionrateofoneofSSTI也，3，5、vas65．3％．InHCCtissues，para-carcinomatissueaIldnomlalliVertissue，t：hehighexpressionratesofSS

6、TR2were29．5‰30．1％aIldOrespectiVely．111edi虢rencebetweengroupswasStatisticallysignificantp

7、iIl戗1reeaboVe—mentionedtissueswere47．4％，71．6％and10％respectiVely(尸