abcg2在肝细胞癌中的表达与其临床意义

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1、达呈阴性。ABCG2在肝细胞癌组织中表达高于在癌旁组织。肝细胞癌及癌旁组织中ABCG2蛋白阳性率分别为60．1％、21．6％，两组相比差异有显著性(妒=15．931，P<0．05)；ABCG2蛋白表达与患者年龄、性别、肿瘤大小及肿瘤数目等均无关(尸均>O．05)；与血清AFP水平、组织分化及淋巴转移有关(P均

2、：ABCG2蛋白在肝细胞癌中异常表达，可能是肝干细胞的潜在标志物；ABCG2是肝细胞癌患者预后不良的危险因素。关键词：肝细胞癌；ABCG2；免疫组织化学1一⋯●’●●●-^’·●Exoressandclinicalsigniticanceolhepaticstem／progenitorceHsmarkerABCG2inhepatocellularcarcinomaABSTRACTobjective-．primaryhepaticcarcinoma(PHC)isacommonmalignancy．Pathogenesisisstillunclea

3、rforPHC．Inrecentyears，thetheorywasputforwardthathumanlivercanceroriginatedinthehepaticstem／progenitorcells．ATPbindingcassettetransporterproteinGfamilymember2(ABCG2)isselectedasthestemcellmarker．TheaimofthepresentstudyistoinvestigatetheexpressionofABCG2inhumanhepatocellularca

4、rcinomaandmatchingtumor-adjacentandnormalliverspecimens，anditsassociationwithclinicopathologicalfeamresandprognosticsignificance．Methods：60casesofHCCspecimensandmatchingtumor-adjacentand7casesofnormallivertissueswerecollectedfrompatientsoperatedinDepartmentofHepatobiliarySur

5、gery,theAffiliatedHospitalofGuilinMedicalCollege，duringMay2009一一July2012．Including42casesofmalesand18cases3offemales，aged30to68years，amedianage50．3years．27casestumordiameter≥5cm，27casestumordiameter<5cm；19casesserumAFP(一)，23casesmultipletumors；29casespoorlydifferentiated，31c

6、aseswelldifferentiated；28caseslymphnodemetastasis．Thespecimenswerefixedin10％formalinandroutinelyembeddedinParaffin．Patientsandtheirfamiliesagreedtoacquirespecimens．Patientshavenopreoperativeradiotherapyandchemotherapy，andpathologicallydiagnosedHCC．ImmunohistochemistryEnVisio

7、nmethodswereutilizedtodetecttheexpressionABCG2inspecimensHCCandmatchingtumor-adjacentandnormallivertissues．Toanalyzeimmunohistochemicalresults，anditsassociationwithclinicpathologicalfeaturesandprognosticsignificance．Results：positiveexpressionismainlylocateinthecancercellintr

8、acytoplasmHCCtissues，toshowdiffusivedistributionborwn-granulo；ABCG2hadbeene