Changing the shape of hair with keratin peptides†用角蛋白肽改变头发的形状

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1、RSCAdvancesViewArticleOnlinePAPERViewJournal

2、ViewIssueChangingtheshapeofhairwithkeratinpeptides†aaabaaCitethis:RSCAdv.,2017,7,51581C.F.Cruz,‡M.Martins,‡J.Egipto,H.Osorio,´A.RibeiroandA.Cavaco-Paulo*Chemicalstraighteningofcurlyhumanhairfibresinvolvestheuseofstrongreducingagentsatalka

3、linepH.Humanhairismadeofkeratin,andthefixationoffibreshapeinvolvesthereductionandreformationofnewdisulphidebondsbetweenkeratinmolecules.Here,weproposeanalternativeandgreenmethodologyusingkeratinpeptidesequences(10–13residues)derivedfromthehumangenome.Inapreviousstudy,weanalysed1235cy

4、steine-containingpeptidesencodedbyallhumangenesofhairkeratinandkeratin-associatedproteins.Thesepeptidefragmentshavebeendesignedbynaturetointeractwithkeratin.Herewetestedeightpeptides,whichwereselectbasedontheiraffinityforhumanhairkeratinsolutionasshownbyMatrix-AssistedLaser-Desorptio

5、nIonizationTime-of-FlightMassSpectrometry(MALDI-TOF/TOF)andbymoleculardynamicssimulation.Thepeptideswerecharacterizedindetailregardingtheirabilitytoactashairstraighteningmodulatorsandtoimprovethetensilestrengthandelasticityofhair.Oftheeighttestedpeptides,PepE,PepGandKPshowedthehigh

6、estabilitytointeractwithCreativeCommonsAttribution-NonCommercial3.0UnportedLicence.akeratinpeptidemodel,andtoimprovehairmechanicalpropertiesandstraighteningefficiency.TheproposedsolutionspresentedherewillreplaceharshreducingagentsatalkalinepHbypeptideReceived20thSeptember2017formulat

7、ionsactingatneutralpHtochangehairshapethroughthere-conformationofdisulphideAccepted26thOctober2017bonds.Here,weprovideexperimentalevidencewhichexplainsatamolecularlevelhowkeratinDOI:10.1039/c7ra10461hdecapeptidescaninteractwithlargekeratinmoleculesinhumanhair,openinganinnovativegre

8、enrsc.li/rsc-advancesapproachtochangingtheshapeofhairfibre.IntroductionrepeatedhairchemicaltreatmentsproduceirreversiblechangesThisarticleislicensedunderainhairtexture,andcanresultinafractureofthehairbreonceThehaircareindustryhasdevelopedaplethoraofproductstothecuticleisremoved,and

9、cortexexposureleadstobreak