Genomic adaptation of ethanologenic yeast to biomass conversion inhibitors英文资料

《Genomic adaptation of ethanologenic yeast to biomass conversion inhibitors英文资料》由会员上传分享，免费在线阅读，更多相关内容在学术论文-天天文库。

1、ApplMicrobiolBiotechnol(2006)73:27–36DOI10.1007/s00253-006-0567-3MINI-REVIEWGenomicadaptationofethanologenicyeasttobiomassconversioninhibitorsZ.LewisLiuReceived:10May2006/Revised:3July2006/Accepted:9July2006/Publishedonline:7October2006#Springer-Verlag2006AbstractOnemajorbarriertotheeconomic

2、conversionofKeywords5-Hydroxymethylfurfural.Biotransformation.biomasstoethanolisinhibitorycompoundsgeneratedFurfural.Genomicexpression.Insitudetoxificationduringbiomasspretreatmentusingdiluteacidhydrolysis.Majorinhibitorssuchasfurfuraland5-hydroxymethylfur-fural(HMF)inhibityeastgrowthandsubs

3、equentfermen-Introductiontation.TheethanologenicyeastSaccharomycescerevisiaedemonstratedadose-dependantinhibitionbytheinhibitorsAsinterestinalternativeenergysourcesrises,theconceptandhasthepotentialtotransformfurfuralandHMFintoofagricultureasanenergyproducerhasbecomeincreas-lesstoxiccompound

4、soffurfurylalcoholand2,5-bis-inglyattractive(Outlawetal.2005).Renewablebiomass,hydroxymethylfuran(alsotermedasfuran-2,5-dimethanolincludinglignocellulosicmaterialsandagriculturalresi-(FDM)),respectively.Forasustainableandcost-competi-dues,arelow-costmaterialsforbioethanolproductiontivebiomas

5、s-to-ethanolindustry,itisimportanttodevelop(BothastandSaha1997;Whealsetal.1999;Zaldivaretmoretolerantyeaststrainsthatcan,insitu,detoxifytheal.2001).Onemajorbarrierofbiomassconversiontoinhibitorsandproduceethanol.Thisstudysummarizesethanolisinhibitorycompoundsgeneratedduringbiomasscurrentknow

6、ledgeandourunderstandingoftheinhibitorspretreatmentusingdiluteacidhydrolysis,whichinterferefurfuralandHMFanddiscussesmetabolicconversionwithmicrobialgrowthandsubsequentfermentation.Furfu-pathwaysoftheinhibitorsandtheyeastgenomicexpres-raland5-hydroxymethylfurfural(HMF)aremajorinhib-sionrespo

7、nsetoinhibitorstress.Unlikelaboratorystrains,itorscommonlyrecognizedfromthebiomasspretreatment.geneexpressionresponseoftheethanologenicyeasttoThegeneticmechanismsinvolvedinstresstolerance,suchfurfuralandHMFwasnottransient,butacontinuedasthosecaused