SERS detection of radiation injury biomarkers in辐射损伤生物标志物的SERS检测 小鼠血清

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1、RSCAdvancesViewArticleOnlinePAPERViewJournal

2、ViewIssueSERSdetectionofradiationinjurybiomarkersinmouseserum†Citethis:RSCAdv.,2018,8,5119abcbcbLianshengLi,RuiXiao,QiWang,ZhenRong,XueqingZhang,ababacabPingkunZhou,HanjiangFu,*ShengqiWang*andZhidongWang*Inalarge-scaleradiologicalcatastrophe,itisexpect

3、edthathundredsandthousandsofpeoplecouldbeexposedtoradiation.Arapidmethodisrequiredfortriageofcasualtiestodeterminepropermedicaltreatment.Inthisarticle,micewereexposedtodifferentradiationdosesandseraofmicewereinvestigatedbysurface-enhancedRamanspectroscopy(SERS)andorthogonalprojectionstolatentstruc

4、turediscriminantanalysis(OPLS-DA)aftertotalbodyirradiation(TBI).Theresultsofthepresentstudyindicatedthatdifferenceshavewidenedovertime.Thedifferentradiationgroupsshowedaslightoverlapat24hand72hbutwerecompletelydistinctatthe10thdayafterTBI.TheSERSspectrumbetweenthenormalgroupandtheirradiatedgroupsho

5、wedasignificantdifferenceat24hours.Thesametrendwasdepictedinscattingscoreplots.SignificantdifferencesinRamanpeakswerefound,CreativeCommonsAttribution-NonCommercial3.0UnportedLicence.Received8thNovember2017
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1suchas744and1495cmcorrespondingtoriboflavinand593and1204cmcorrespondingtoL-Accepted19thJanuar

6、y2018tryptophan.ThelackofriboflavinandL-tryptophanwillinfluencemetabolismlevels.Aboveall,theseDOI:10.1039/c7ra12238aresultsbearpotentialinthedevelopmentoflabel-freeandrapidtoolsforon-sitedetectionandrsc.li/rsc-advancesscreeningofirradiationinjuries.IntroductionfreeSERSdetectionwaswidelyusedindiffere

7、ntserumstudies.4–7PatientswereseparatedfromnormalindividualsDuringalarge-scaleradiologicalevent,hundredsofthousandsusingstatisticalformulas.AndvariationsofcomponentsposingThisarticleislicensedunderasignicanteffectsondiseases8,9werealsodetectedbyusingthisofindividualsmaybeexposedtoradiationandneed

8、emergencytreatment,soarapidbiodosimetricmethodisrequiredformethod.triageofcasualtiestodeterminepropermedicaltreatment.Ag(Au)NPshasbeenreportedasanoptimumnanoparticlesOpenAccessArticle.Publishedon29January2018.Downloade