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1、ClinicalInfectiousDiseasesIDSAGUIDELINEClinicalPracticeGuidelinefortheManagementofCandidiasis:2016UpdatebytheInfectiousDiseasesSocietyofAmerica12345678PeterG.Pappas,CarolA.Kauffman,DavidR.Andes,CorneliusJ.Clancy,KierenA.Marr,LuisOstrosky-Zeichner,AnnetteC.Reboli,MindyG.Schuster,
2、9101112JoseA.Vazquez,ThomasJ.Walsh,TheoklisE.Zaoutis,andJackD.Sobel1234UniversityofAlabamaatBirmingham;VeteransAffairsAnnArborHealthcareSystemandUniversityofMichiganMedicalSchool,AnnArbor;UniversityofWisconsin,Madison;Universityof567Pittsburgh,Pennsylvania;JohnsHopkinsUniversity
3、SchoolofMedicine,Baltimore,Maryland;UniversityofTexasHealthScienceCenter,Houston;CooperMedicalSchoolofRowanUniversity,891011Camden,NewJersey;UniversityofPennsylvania,Philadelphia;GeorgiaRegentsUniversity,Augusta;WeillCornellMedicalCenterandCornellUniversity,NewYork,NewYork;Child
4、ren’s12HospitalofPennsylvania,Philadelphia;andHarperUniversityHospitalandWayneStateUniversity,Detroit,MichiganItisimportanttorealizethatguidelinescannotalwaysaccountforindividualvariationamongpatients.Theyarenotintendedtosupplantphysicianjudgmentwithrespecttoparticularpatientsor
5、specialclinicalsituations.IDSAconsidersadherencetotheseguidelinestobevoluntary,withtheultimatedeterminationregardingtheirapplicationtobemadebythephysicianinthelightofeachpatient’sindividualcircumstances.Keywords.candidemia;invasivecandidiasis;fungaldiagnostics;azoles;echinocandi
6、ns.EXECUTIVESUMMARYthePediatricInfectiousDiseasesSociety(PIDS).TheMycosesStudyGroup(MSG)hasalsoendorsedtheseguidelines.TheBackgroundpanelfollowedaguidelinedevelopmentprocessthathasbeenInvasiveinfectionduetoCandidaspeciesislargelyaconditionas-adoptedbytheInfectiousDiseasesSociety
7、ofAmericasociatedwithmedicalprogress,andiswidelyrecognizedasamajor(IDSA),whichincludesasystematicmethodofgradingbothcauseofmorbidityandmortalityinthehealthcareenvironment.thequalityofevidence(verylow,low,moderate,andhigh)Thereareatleast15distinctCandidaspeciesthatcausehumandis-a
8、ndthestrengthoftherecommendation(weakorstrong)[
