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《关于安卓健的学术论文-安卓健对乳腺癌细胞的诱导作用》由会员上传分享，免费在线阅读，更多相关内容在教育资源-天天文库。
1、论文标题：安卓健对乳腺癌细胞的诱导作用论文摘要：乳腺癌是全世界最流行的妇科癌症，同时乳腺癌也是全球第二大（除肺癌）造成妇女死亡的癌症。本研究，我们通过老鼠实验证实萃取自牛樟芝的环乙烯酮化合物—安卓健对乳腺癌细胞具有明显的抑制其成长，促使其凋亡的作用。我们将80只雌性大白鼠分为五组，分别为AC低剂量组（喂食0.25g牛樟芝菌丝体每千克体重）、AC高剂量组（喂食0.5g牛樟芝菌丝体每千克体重）、安卓健低剂量组（喂食15mg安卓健每千克体重）、安卓健高剂量组（喂食30mg安安卓健每千克体重）、紫杉醇组（喂食5mg紫杉醇每千克体重）
2、。实验结果显示，无论是牛樟芝组、安卓健组还是紫杉醇组，小于10mm的乳腺肿瘤均显著地缩小。但是，大于10mm的乳腺肿瘤只在安卓健组观察到显著缩小。同时发现，高剂量的牛樟芝组比低剂量的牛樟芝组，乳腺肿瘤的缩小程度更显著，并且在高剂量的牛樟芝组，小于10mm的乳腺肿瘤在17周内没有出现复发现象。英文版本论文全文如下：Name：Antrodiacamphorateextractanditspurifiedcompound-AntroquinonolorallytreatsN-methyl-N-nitrosourea-induced
3、breastcancerSummary:Antrodiacamphoratepossessesanti-breastcanceractivityTheGoldenBiotechnologyCorp..camphoratainitiatedbythecompany,manyexpertsinvolvedinthestudythemechanismforthetreatmentofbreastcancerRelatedresearch.StudieshaveshownthatA.camphoratawithanti-cancer
4、activity.Li-HsuenChen1,Wei-ChihYang1,Gain-HeFang1,Mao-TienKuo2,Wu-CheWen2,PeiniChen3,Ching-FengWeng1*1DepartmentofLifeScienceandtheInstituteofBiotechnology,NationalDong–HwaUniversity,Hualien974,Taiwan.2GoldenBiotechnologyCorp.,DanshueiTownship,TaipeiCounty251,Taiwa
5、n.3DepartmentofRadiology,TaipeiVeteransGeneralHospital,Taipei112,Taiwan.*TowhomcorrespondenceandreprintrequestsshouldbemadeRunningtitle:Antrodiacamphoratepossessesanti-breastcanceractivity____________________________________________________________*Correspondingaut
6、hor.Tel.:+88638633637;fax:+88638630255.E-mailaddress:cfweng@mail.ndhu.edu.tw(Ching-FengWeng).AbstractBreastcanceristhemostprevalentcancerinwomenworldwide,excludingnon-melanomaskincancer,andisthesecondleadingcauseofcancerdeathsinwomen(followinglungcancer).Inthisstud
7、y,Antrodiacamphoratemyceliumwithmediumextract(AC)anditspurifiedcompound-AntroquinonolwereappliedtotreatinsitubreastcancerinanN-methyl-N-nitrosourea(MNU)-inducedratmodeltoevaluatethetherapeuticpotentialofA.camphorate.EightyfemaleSprague-Dawleyrats(21daysold)werefeda
8、dlibitumwithstandardratchowandwereinjectedintraperitoneallythreetimeswith25mgMNU/kgBwt.Ratswerepalpatedeveryweektocheckthesizeofthetumorsandthetu
