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1、实用医学杂志2007年第23卷第4期461利多卡因对失血性休克兔细胞因子的影响刘莹莹林春水阮骆阳古妙宁摘要目的:探讨利多卡因对失血性休克再灌注兔细胞因子的影响。方法:18只白兔随机分为3组,每组6只,利多卡因组(L组)、失血性休克组(H组)和对照组(C组)。L组于放血前静脉注射利多卡因2.5mg/kg,此后每隔1h静注利多卡因1mg/kg维持,L组与H组建立失血性休克模型后,分别于放血前、失血性休克2h、再灌注2h各从股静脉取血测定血浆肿瘤坏死因子-α(TNF-α)和白细胞介素-6(IL-6)含量,C组在上述对应时间点测定血浆TNF-α和IL-6含
2、量。结果:C组TNF-α和IL-6含量各时间点比较差异无显著性(P>0.05);H组与L组在休克2h、再灌注2hTNF-α和IL-6含量与放血前相比均明显升高(P<0.05),且呈上升趋势;与H组相比,L组休克2h、再灌注2hTNF-α和IL-6含量均明显下降(P<0.05)。结论:早期小剂量静注利多卡因能减少失血性休克兔促炎细胞因子TNF-α和IL-6含量,从而对机体产生一定的保护作用。关键词休克,出血性利多卡因细胞因子类兔Effectsoflidocaineoninflammatorycytokineduringhemorrhagicshock
3、inrabbitsLIUYing-ying,LINChun-shui,RUANLuo-yang,GUMiao-ning.DepartmentofAnesthesiology,NanfangHospitalofNanfangMedicalUniversity,Guangzhou510515,China【Abstract】ObjectiveToobservetheeffectsoflidocaineoninflammatorycytokineduringhemorrhagicshockinrabbits.MethodsEighteenrabbitswe
4、rerandomlydividedintothreegroups:lidocainegroup(GroupL,n=6),hemorrhagicshockgroup(GroupH,n=6)andcontrolgroup(GroupC,n=6).Hemorrhagicshockmodelwassetupbybloodlettinginrabbits.Lidocaine(2.5mg/kg)wasintravenouslygivenbeforebloodletting,andthenlidocaine1mg/kgonceperhourforthreetim
5、es.Bloodsamplesoffemoralveinwerecollectedformeasurementofplasmatumornecrosisfactor-α(TNF-α)andinterleukin-6(IL-6)beforebloodletting,2hoursafterhemorrhagicshockand2hoursafterreperfusion.ResultsPlasmaTNF-αandIL-6levelsobviouslyincreaseedat2hoursafterhemorrhagicshockand2hoursafte
6、rreperfusioninGroupHandGroupL,whichweresignificantlyhigherthanthoseinGroupCandbeforebloodletting(P<0.05)andweremarkablylowerinGroupLthanthoseinGroupH(P<0.05).ConclusionLidocainecanremarkablyinhibitthereleasesoftheinflammatorycytokinesoccurredduringhemorrhagicshock.【Keywords】Sh
7、ock,hemorrhagicLidocaineCytokinesRabbits失血性休克时有效循环血量减少和组织低灌流,多卡因1mg/kg维持,H组和L组均在15min后经导致器官功能障碍,严重的情况下可致器官衰竭。近右股动脉放血至平均动脉压(40±5)mmHg维持60年来研究发现利多卡因除了局部麻醉及抗心律失常min制成失血性休克模型,并间断回输或放血维持此作用外,还可稳定细胞膜,参与调节炎症反应[1-2]血压,2h后快速回输全部自体抗凝血并追加输入等。本实验通过观察利多卡因对失血性休克兔放血前、休克量的乳酸林格氏液。2h及再灌注2h血浆肿瘤坏
8、死因子-α(TNF-α)和白1.2观察指标TNF-α和IL-6采用酶联免疫吸附试细胞介素-6(IL-6)含量的影响,旨在探
