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1、新疆医科大学学报JOURNALOFXINJIANGMEDICALUNIVERSITY2007Jan.,30(1)61眼科门诊干眼患病状况及相关因素调查分析3张宏,安晓,陈雪艺(新疆医科大学第一附属医院眼科,新疆乌鲁木齐830054)摘要:目的:了解眼科门诊患者中干眼患病状况及相关因素。方法:以2005年4～6月及9～11月间眼科门诊就诊的650例患者作为研究对象,年龄>30岁,在获得知情同意以后进行问卷调查和干眼相关检查,先对干眼症状阳性者进行泪膜破裂时间(BUT)试验,再对其中BUT<10s者进行角结膜荧光素染色、睑板腺功能检查、基础泪液分泌试验及虎红染色4项客观检查。结果:干眼总患病
2、率为20.6%,女性(26.2%)高于男性(15.0%)(P<0.001);眼部不适症状中最多见的是干涩感182例(28.0%),其次为疲劳感158例(24.3%),最少见的症状为眼痛42例(6.5%);泪膜破裂时间平均为(9.93±2.91)s,男性为(10.55±2.30)s,长于女性的(9.30±3.30)s,P<0.001;泪膜破裂时间随年龄增长而缩短,60岁以上年龄组泪膜破裂时间短于60岁以下年龄组(P<0.05),70岁以上年龄组泪膜破裂时间最短,为(7.16±3.52)s,与60～69岁组相比差异有统计学意义(P<0.05)。结论:眼科门诊干眼的患病率与年龄、性别相关。关键
3、词:干眼;泪膜破裂时间;影响因素中图分类号:R591.41文献标识码:A文章编号:100925551(2007)0120061203InvestigationofdryeyeinophthalmicoutpatientsZHANGHong,ANXiao,CHENXue2yi(DepartmentofOphthalmology,FirstAffiliatedHospital,XinjingMedicalUniversity,Urumqi830054,China)Abstract:Objective:Tostudytheprevalenceofdryeyeinahospital2basedp
4、opulationandanalyzethecau2sesofdryeye.Methods:Atotalof600newoutpatientsageabove30yearswerescreenedfordryeyefromApriltoMay2005andSectembertoOctorbor2005.Afterinformedconsentwasobtainedfromsubjects,aquestionnairewasdone.Whenarespondentindicatedthepresenceofsymptom,BUTtestwasperformed,subjectswhoset
5、hevalueofBUT<10swereundergonethedryeyetestincluding:fluoresceinstainingtest,meibomianglandfunction,SchirmerItest,rosebasal;thenahospital2basedcase2controlstudywasconductedtothosesubjectswhoweredeemedtobesufferingfromdryeye,twomatchedcontrolsperdryeyecasewererandomlyselected.Multivariateconditiona
6、llogisticregressionmodelwasusedforunivari2ableandmultivariateanalysis.Results:Sixhundredandfiftypeopleparticipated;theyrangedinagefrom30～83years(withameanof49.9yars).Dryeyewaspresentin134(20.6%)ofthestudysubjects,itwassignificantlyhigher(P<0.001)infemales(26.2%)thaninmales(15.0%);onanalysingthepr
7、esen2tingcomplaints,themostcommoncomplaintwasdryness,foundin182(28.0%)subjects,followedbyocularfatigue158(24.3%)andthemostleastcomplaintwasocularpainin42(6.5%).In650subjectsthemeanvalueofBUTwas(9.93±2.91)seconds.Inmale
