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1、#50#中国实用妇科与产科杂志2008年1月第24卷第1期论著文章编号:1005-2216(2008)01-0050-03胚胎冷冻及复苏移植120个周期临床效果分析夏蕾,王卓然,张洪秀,张雅娟,刘彬,吕荟明,韩向阳摘要:目的探讨冷冻胚胎复苏移植后的妊娠结局。方法2003年1月至2007年5月,对2~4细胞期胚胎进行慢速冷冻保存,快速复苏及移植,共有88例患者在哈尔滨医科大学第一临床医学院进行了120个周期的冷冻胚胎复苏移植,观察冷冻复苏移植的效果。结果复苏胚胎370个,存活316个,完整存活胚胎232个,移植316个胚胎,临床妊娠39例,妊娠率为3215%(39/120)。胚胎种植率1615%
2、(52/316)。比较妊娠组与非妊娠组在年龄、雌二醇水平、子宫内膜厚度、胚胎复苏存活率及完整存活率上差异均无显著性意义(P>0105),优质胚胎率差异有极显著性意义(P<0101)。结论优质胚胎是移植后获得妊娠的关键,采用冻融胚胎移植技术可以提高辅助生殖技术的累计妊娠率。关键词:冻融胚胎移植;优质胚胎;妊娠中图分类号:R71文献标志码:AAnalysisoftheclinicaloutcomesofhumanembryotransplantationafterfrozen-thawingprotoco:l120cycles.XIALei,WANGZhuo-ran,ZHANGHong-xiu,Z
3、HANGYa-juan,LIUBin,LU&Hui-ming,HANXiang-yang.Repro-ductiveMedicalCenter,TheFirstAffiliatedHospitalofHarbinMedicalUniversity,Harbin150001,ChinaAbstract:ObjectiveToinvestigatetheoutcomesofembryonictransplantationaftercryopreservationandthawing.MethodsAslow-freezingandrapid-thawingprotocolwasusedinhuma
4、nembryosat2~4cellsstage.Theclinicalou-tcomesaftertransferofthefrozen/thawedembryosin120cycleswereanalysed.Eighty-eightpatientsaccepted120cyclesoffrozen/thawedembryotransferintheFirstAffiliatedHospitalofHarbinMedicalUniversityfromJanuary2003toMay20071ResultsAtotalof370embryoswerethawed,ofwhich316embr
5、yossurvivedand232embryossurvivedintactly.Threehundredandsixteenembryosweretransferred.Theclinicalpregnancyratewas3215%(39/120)andtheimplanta-tionratewas1615%(52/316).Therewasnosignificantdifferenceinage,serumestrogenlevels,endometriumthick-ness,survivalratesoffrozen/thawedembryosandintactsurvivalrat
6、esbetweenpregnancygroupandnon-pregnancyone(P>0105).However,thegood-qualityembryosratiowassignificantlyhigherinthepregnancygroupthanthatinnon-pregnancyone(P<0101).ConclusionThequalityofembryohasasignificanteffectontheclinicalpregnancyratea-ftertransferoffrozen/thawedembryos.Accumulativepregnancyratei
7、nIVFprotocolmayincreaseutilizingtransplantationoffrozen/thawedembryos.keywords:frozen-thawedembryotransfer;goodqualityembryo;pregnancy1983年澳大利亚Trounson等通过冻融胚胎移植(fro-胎数目不超过3个,剩余胚胎进行冷冻保存。此外,当患者zen-thawe
