术前IFN联合DDP、VP-16腹腔化疗治疗晚期卵巢癌合并腹水37例临床体会

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1、284辽宁医学杂志2010年第24卷第6期术前IFN联合DDP、VP一16腹腔化疗治疗晚期卵巢癌合并腹水37例临床体会江苏省南京医科大学附属无锡市妇幼保健院肿瘤科(214002)张晔杨幼易江静颖【摘要】目的对晚期卵巢上皮性癌合并腹水的患者给予术前干扰素(IFN)联合顺铂(DDP)、足叶乙甙(VP—l6)腹腔化疗，探讨IFN提高化疗疗效的作用。方法本研究纳入37例晚期卵巢上皮性癌患者(FIGO分期mC期)，术前给予DDP+VP，16腹腔化疗2个疗程，加用IFN(A纽)21例，未用IFN(B纽)16例。比

2、较2纽行肿瘤细胞减灭术后的疗效。结果术后通过手术标本的镜检分析证实，A组与B组相比标本中癌细胞较多发生中、重度化疗反应，有些瘤组织大片坏死，细胞界限不清，甚至有抑制核分裂的表现，从而使肿瘤细胞活性大大降低，但2组比较差异无显著性(P>0．05)。A纽的全部缓解率(cR)为72％，与B组(56％)相比较，差异元显著性(P>0．05)；但从总有效率(CR+PR)来看，A组(89％)较B组(62％)有显著性差异(P<0．05)。A、B两组化疗毒副作用比较差异无显著性(P>0．05)。结论应用IFN联合DDP

3、、VP．16术前腹腔化疗方案，能够更有效地杀灭癌细胞，控制腹水和缩小病灶，提高手术质量和治疗效果。【关键词】卵巢上皮性癌腹腔化疗干扰素皿NcombinationDDP、、，P-16preoperativeintraperRonealchemotherapyforthetreatmentofad-vancedepithelialovariancancerwitllascitesZhangYe，yn，Jiang~ngying．HospitalforMaternalandChildHealthCare，Ji

4、angsu，214002，China【Abstract]ObjectiveThepurposeofthisstudyWastoevaluatediferencesinthetl／／norremissionrateinwomenwithadvancedepithelialovariancarcinoma(EOC)treatedwithDDP+VP一16preoperativeintraperitonealchemotherapycombi-nationwithorwithoutIF．N．MethodsI

5、narandomized，retrospectivestudy，allpatientswiⅡladvancedEOCofFIGOstageⅢcandaseitesweretreatedbetween2002and2009atoilrhospital，andreceived2cyclesofDDP+VP-16preoperativein-trapefitonealchemotherapy．21patientsreceivedcombinationchemotherapywi廿1IFN(Agroug)an

6、d16patientsreceivedcombinationchemotherapywithoutIFN(Bgroup)fonowedbytulnordebulkingsurgery．Thetwogroupswereinvestigatedandcomparedwithrespecttotumorremissionrate．Resultsoptnxacytoredactonwasachievedmoreofteninpaten~whoreceivedcombinationchemotherapywit

7、llIFN．Thecompleterate(CR)ofAgroup(72％)wasnotsignificantlythanAgroup(56％)．However，thetotalremissionrate(CR+PR)forpatientsmanagedwith1FN(Agroup，89％)wasstatisticallysignificantlysuperiorcomparedtopatientstreatedwithoutIFN(Agroup，62％)(P>0．05)．ConduslonsHigh

8、ertumorremissionrateandsafecallbeachievedinthesepatientswithadvancedEOCofFIGOstagemewithascitesbythe11BeofDDP+VP一16preoperativeintraperitonealchemotherapy．PatientswillbenefitfromcombinationwithIFN．【Keywords】epithelia／ovariancance